Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development

doi:10.3389/fcell.2022.967147

	Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development
	Paniagua, Steven 1; Cakir, Bilal 1; Hu, Yue 2; Kiral, Ferdi Ridvan 1; Tanaka, Yoshiaki 1,3; Xiang, Yangfei4 ; Patterson, Benjamin 1; Gruen, Jeffrey R.5,6; Park, In-Hyun 1
	2022-08-09
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
卷号	10
发表状态	已发表
DOI	10.3389/fcell.2022.967147
摘要	Dyslexia, also known as reading disability, is defined as difficulty processing written language in individuals with normal intellectual capacity and educational opportunity. The prevalence of dyslexia is between 5 and 17%, and the heritability ranges from 44 to 75%. Genetic linkage analysis and association studies have identified several genes and regulatory elements linked to dyslexia and reading ability. However, their functions and molecular mechanisms are not well understood. Prominent among these is KIAA0319, encoded in the DYX2 locus of human chromosome 6p22. The association of KIAA0319 with reading performance has been replicated in independent studies and different languages. Rodent models suggest that kiaa0319 is involved in neuronal migration, but its role throughout the cortical development is largely unknown. In order to define the function of KIAA0319 in human cortical development, we applied the neural developmental model of a human embryonic stem cell. We knocked down KIAA0319 expression in hESCs and performed the cortical neuroectodermal differentiation. We found that neuroepithelial cell differentiation is one of the first stages of hESC differentiation that are affected by KIAA0319 knocked down could affect radial migration and thus differentiation into diverse neural populations at the cortical layers.
关键词	KIAA0319 cell cycle hESCs NPCs differentiation
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	CSCRF["R01MH118344-01A1","R01MH118554-01A1"] ; Kavli Foundation[16-RMB-YALE-04] ; [R15 HD087937] ; [P50 HD027802] ; [R01 HG010171]
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
WOS记录号	WOS:000843842800001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/219649
专题	生命科学与技术学院_PI研究组_向阳飞组
通讯作者	Gruen, Jeffrey R.; Park, In-Hyun
作者单位	1.Yale Stem Cell Ctr, Yale Sch Med, Dept Genet, New Haven, CT 06520 USA 2.Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA 3.Univ Montreal, Maisonneuve Rosemont Hosp Res Ctr, Dept Med, Montreal, PQ, Canada 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 5.Yale Sch Med, Dept Pediat, New Haven, CT 06510 USA 6.Yale Sch Med, Dept Genet, New Haven, CT 06510 USA
推荐引用方式 GB/T 7714	Paniagua, Steven,Cakir, Bilal,Hu, Yue,et al. Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10.
APA	Paniagua, Steven.,Cakir, Bilal.,Hu, Yue.,Kiral, Ferdi Ridvan.,Tanaka, Yoshiaki.,...&Park, In-Hyun.(2022).Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10.
MLA	Paniagua, Steven,et al."Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022).