The Role of Stroma in Tumor Development

doi:10.1097/PPO.0000000000000127

	The Role of Stroma in Tumor Development
	Werb, Zena 1; Lu, Pengfei1,2
	2015-07-01
发表期刊	CANCER JOURNAL
ISSN	1528-9117
卷号	21 期号:4 页码:250-253
发表状态	已发表
DOI	10.1097/PPO.0000000000000127
摘要	The tumor microenvironment plays an essential role in various stages of cancer development. This environment, composed of the extracellular matrix, fibroblasts, endothelial cells, and cells of the immune system regulates the behavior of and co-evolve with tumor cells. Many of the components, including the innate and adaptive immune cells, play multifaceted roles during cancer progression and can promote or inhibit tumor development, depending on local and systemic conditions. Interestingly, a strategy by which tumor cells gain drug resistance is by modifying the tumor microenvironment. Together, understanding the mechanisms by which the tumor microenvironment functions should greatly facilitate the development of new therapeutic interventions by targeting the tumor niche.
关键词	Adaptive immunity carcinoma-associated fibroblasts chemoresistance exosomes microvesicles extracellular matrix innate immunity matrix metalloproteinases tumor microenvironment
收录类别	SCI
语种	英语
资助项目	National Institutes of Health[R01 CA057621] ; National Institutes of Health[R01 CA138818] ; National Institutes of Health[U01 ES019458]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000359820200004
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS关键词	CANCER-RELATED INFLAMMATION ; MYELOID CELLS ; BONE-MARROW ; STEM-CELLS ; MATRIX METALLOPROTEINASES ; COLLECTIVE INVASION ; MALIGNANT PHENOTYPE ; CARCINOMA-CELLS ; TGF-BETA ; MICROENVIRONMENT
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2185
专题	生命科学与技术学院_PI研究组_吕鹏飞组
通讯作者	Werb, Zena
作者单位	1.Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Werb, Zena,Lu, Pengfei. The Role of Stroma in Tumor Development[J]. CANCER JOURNAL,2015,21(4):250-253.
APA	Werb, Zena,&Lu, Pengfei.(2015).The Role of Stroma in Tumor Development.CANCER JOURNAL,21(4),250-253.
MLA	Werb, Zena,et al."The Role of Stroma in Tumor Development".CANCER JOURNAL 21.4(2015):250-253.