PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3

doi:10.1038/s41388-022-02418-3

	PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3
	Zheng, Qian-Wen1,2 ; Ni, Qian-Zhi 1; Zhu, Bing 1; Liang, Xin 1; Ma, Ning 3; Wang, Yi-Kang 1; Xu, Sheng 1; Cao, Hui-Jun 1; Xia, Ji 1; Zhang, Feng-Kun 1; Zhang, Er-Bin 1; Qiu, Xiao-Song1,2 ; Ding, Xu-Fen 1; Qiu, Lin 1; Zhang, Xi-Lin 4; Dong, Zhao-Hui 5; Li, Zhi-Gang 3; Zhang, Xue-Li 6; Xie, Dong1,2,7 ; Li, Jing-Jing 1
	2022-09-02
发表期刊	ONCOGENE (IF:6.9[JCR-2023],7.5[5-Year])
ISSN	0950-9232
EISSN	1476-5594
发表状态	已发表
DOI	10.1038/s41388-022-02418-3
摘要	Lung cancer is the most common malignancy and the leading cause of cancer death worldwide, and lung adenocarcinoma (LUAD) is the most prevalent subtype. Considering the emergence of resistance to therapies, it is urgent to develop more effective therapies to improve the prognosis. Here we reported that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) deficiency inhibited LUAD development both in vitro and in vivo. Mechanistically, PPDPF induces hyperactive STAT3 by interfering STAT3-PTPN1 interaction. Activated STAT3 promoted BMPR2 transcription, which further inhibited apoptosis. Moreover, PPDPF reduced NK cell infiltration and activation to develop an immunosuppressive microenvironment, which was also mediated by STAT3. Furthermore, we identified that the expression of PPDPF was positively correlated with the malignant features of LUAD, as well as BMPR2 and p-STAT3 level in clinical samples. Therefore, our study suggests that PPDPF positively regulates BMPR2 expression and facilitates immune escape via regulating STAT3 activity, providing a potential therapy target for LUAD.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China["82172950","81972757","81730083","82030084"] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2017324]
WOS研究方向	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS记录号	WOS:000832824600002
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214792
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_谢东组
通讯作者	Zhang, Xue-Li; Xie, Dong; Li, Jing-Jing
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Thorac Surg, Sect Esophageal Surg, Shanghai 200030, Peoples R China 4.Huzhou Univ, Affiliated Hosp 1, Dept Cent Lab, Huzhou 313000, Zhejiang, Peoples R China 5.Huzhou Univ, Affiliated Hosp 1, Dept Crit Care Med, Huzhou 313000, Zhejiang, Peoples R China 6.Shanghai Fengxian Cent Hosp, Dept Gen Surg, Shanghai 201499, Peoples R China 7.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zheng, Qian-Wen,Ni, Qian-Zhi,Zhu, Bing,et al. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3[J]. ONCOGENE,2022.
APA	Zheng, Qian-Wen.,Ni, Qian-Zhi.,Zhu, Bing.,Liang, Xin.,Ma, Ning.,...&Li, Jing-Jing.(2022).PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3.ONCOGENE.
MLA	Zheng, Qian-Wen,et al."PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3".ONCOGENE (2022).