Endogenous Proteins Modulation in Live Cells with Small Molecules and Light
2022-07
发表期刊CHEMBIOCHEM (IF:2.6[JCR-2023],2.8[5-Year])
ISSN1439-4227
EISSN1439-7633
发表状态已发表
DOI10.1002/cbic.202200244
摘要

Protein modulation by light illumination enables the investigation of biological function in high spatiotemporal precision. Compared to genetic methods, the small molecule approach is uniquely suited for modulating endogenous proteins. Endogenous protein modulation in live cells with small molecules and light has recently advanced on three distinctive frontiers: i) the infrared-light-induced or localized decaging of small molecules by photolysis, ii) the visible-light-induced photocatalytic releasing of small molecules, and iii) the small-molecule-ligand-directed caging for photomodulation of proteins. Together, these methods provide powerful chemical biology tool kits for spatiotemporal modulation of endogenous proteins with potential therapeutic applications. This Concept article aims to inspire organic chemists and chemical biologists to delve into this burgeoning endogenous protein modulation field for new biological discoveries.

关键词endogenous proteins modulation live cells photocatalysis photolysis small molecules
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收录类别SCI ; SCIE
语种英语
资助项目National Natural Science Foundation of China[
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal
WOS记录号WOS:000832599900001
出版者WILEY-V C H VERLAG GMBH
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214791
专题物质科学与技术学院_博士生
物质科学与技术学院_特聘教授组_陈以昀组
通讯作者Chen, Yiyun
作者单位
1.Chinese Acad Sci, Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,State Key Lab Bioorgan &, 345 Lingling Rd, Shanghai 200032, Peoples R China
2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, 1 Sublane Xiangshan, Hangzhou 310024, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Zeng, Kaixing,Han, Lili,Chen, Yiyun. Endogenous Proteins Modulation in Live Cells with Small Molecules and Light[J]. CHEMBIOCHEM,2022.
APA Zeng, Kaixing,Han, Lili,&Chen, Yiyun.(2022).Endogenous Proteins Modulation in Live Cells with Small Molecules and Light.CHEMBIOCHEM.
MLA Zeng, Kaixing,et al."Endogenous Proteins Modulation in Live Cells with Small Molecules and Light".CHEMBIOCHEM (2022).
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