ShanghaiTech University Knowledge Management System
Endogenous Proteins Modulation in Live Cells with Small Molecules and Light | |
2022-07 | |
发表期刊 | CHEMBIOCHEM (IF:2.6[JCR-2023],2.8[5-Year]) |
ISSN | 1439-4227 |
EISSN | 1439-7633 |
发表状态 | 已发表 |
DOI | 10.1002/cbic.202200244 |
摘要 | Protein modulation by light illumination enables the investigation of biological function in high spatiotemporal precision. Compared to genetic methods, the small molecule approach is uniquely suited for modulating endogenous proteins. Endogenous protein modulation in live cells with small molecules and light has recently advanced on three distinctive frontiers: i) the infrared-light-induced or localized decaging of small molecules by photolysis, ii) the visible-light-induced photocatalytic releasing of small molecules, and iii) the small-molecule-ligand-directed caging for photomodulation of proteins. Together, these methods provide powerful chemical biology tool kits for spatiotemporal modulation of endogenous proteins with potential therapeutic applications. This Concept article aims to inspire organic chemists and chemical biologists to delve into this burgeoning endogenous protein modulation field for new biological discoveries. |
关键词 | endogenous proteins modulation live cells photocatalysis photolysis small molecules |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[ |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
WOS记录号 | WOS:000832599900001 |
出版者 | WILEY-V C H VERLAG GMBH |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214791 |
专题 | 物质科学与技术学院_博士生 物质科学与技术学院_特聘教授组_陈以昀组 |
通讯作者 | Chen, Yiyun |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,State Key Lab Bioorgan &, 345 Lingling Rd, Shanghai 200032, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, 1 Sublane Xiangshan, Hangzhou 310024, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Zeng, Kaixing,Han, Lili,Chen, Yiyun. Endogenous Proteins Modulation in Live Cells with Small Molecules and Light[J]. CHEMBIOCHEM,2022. |
APA | Zeng, Kaixing,Han, Lili,&Chen, Yiyun.(2022).Endogenous Proteins Modulation in Live Cells with Small Molecules and Light.CHEMBIOCHEM. |
MLA | Zeng, Kaixing,et al."Endogenous Proteins Modulation in Live Cells with Small Molecules and Light".CHEMBIOCHEM (2022). |
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