Growth suppressor lingerer regulates bantam microRNA to restrict organ size
2015-10
Source PublicationJOURNAL OF MOLECULAR CELL BIOLOGY
ISSN1674-2788
Volume7Issue:5Pages:415-428
Status已发表
DOI10.1093/jmcb/mjv045
AbstractThe evolutionarily conserved Hippo signaling pathway plays an important role in organ size control by regulating cell proliferation and apoptosis. Here, we identify Lingerer (Lig) as a growth suppressor using RNAi modifying screen in Drosophila melanogaster. Loss of lig increases organ size and upregulates bantam (ban) and the expression of the Hippo pathway target genes, while overexpression of lig results in diminished ban expression and organ size reduction. We demonstrate that Lig C-terminal exhibits dominant-negative function on growth and ban expression, and thus plays an important role in organ size control and ban regulation. In addition, we provide evidence that both Yki and Mad are essential for Lig-induced ban expression. We also show that Lig regulates the expression of the Hippo pathway target genes partially via Yorkie. Moreover, we find that Lig physically interacts with and requires Salvador to restrict cell growth. Taken together, we demonstrate that Lig functions as a critical growth suppressor to control organ size via ban and Hippo signaling.
Keywordlingerer Hippo Salvador Yorkie Mad organ size control bantam
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31171394] ; National Natural Science Foundation of China[31371462]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000363201800004
PublisherOXFORD UNIV PRESS
WOS KeywordHIPPO SIGNALING PATHWAY ; CONTROLS TISSUE-GROWTH ; CELL-CYCLE EXIT ; TUMOR-SUPPRESSOR ; PROMOTES APOPTOSIS ; TEAD/TEF FAMILY ; PROTEIN-KINASE ; HUMAN CANCER ; YAP PATHWAY ; DROSOPHILA
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2123
Collection生命科学与技术学院_特聘教授组_赵允组
生命科学与技术学院_特聘教授组_张雷组
Corresponding AuthorZhang, Lei
Affiliation
1.Chinese Acad Sci, State Key Lab Cell Biol, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
2.Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Dong, Liang,Li, Jinhui,Huang, Hongling,et al. Growth suppressor lingerer regulates bantam microRNA to restrict organ size[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(5):415-428.
APA Dong, Liang.,Li, Jinhui.,Huang, Hongling.,Yin, Meng-Xin.,Xu, Jinjin.,...&Zhang, Lei.(2015).Growth suppressor lingerer regulates bantam microRNA to restrict organ size.JOURNAL OF MOLECULAR CELL BIOLOGY,7(5),415-428.
MLA Dong, Liang,et al."Growth suppressor lingerer regulates bantam microRNA to restrict organ size".JOURNAL OF MOLECULAR CELL BIOLOGY 7.5(2015):415-428.
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