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| Growth suppressor lingerer regulates bantam microRNA to restrict organ size | |
| 2015-10 | |
| Source Publication | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| ISSN | 1674-2788 |
| Volume | 7Issue:5Pages:415-428 |
| Status | 已发表 |
| DOI | 10.1093/jmcb/mjv045 |
| Abstract | The evolutionarily conserved Hippo signaling pathway plays an important role in organ size control by regulating cell proliferation and apoptosis. Here, we identify Lingerer (Lig) as a growth suppressor using RNAi modifying screen in Drosophila melanogaster. Loss of lig increases organ size and upregulates bantam (ban) and the expression of the Hippo pathway target genes, while overexpression of lig results in diminished ban expression and organ size reduction. We demonstrate that Lig C-terminal exhibits dominant-negative function on growth and ban expression, and thus plays an important role in organ size control and ban regulation. In addition, we provide evidence that both Yki and Mad are essential for Lig-induced ban expression. We also show that Lig regulates the expression of the Hippo pathway target genes partially via Yorkie. Moreover, we find that Lig physically interacts with and requires Salvador to restrict cell growth. Taken together, we demonstrate that Lig functions as a critical growth suppressor to control organ size via ban and Hippo signaling. |
| Keyword | lingerer Hippo Salvador Yorkie Mad organ size control bantam |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31171394] ; National Natural Science Foundation of China[31371462] |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| WOS ID | WOS:000363201800004 |
| Publisher | OXFORD UNIV PRESS |
| WOS Keyword | HIPPO SIGNALING PATHWAY ; CONTROLS TISSUE-GROWTH ; CELL-CYCLE EXIT ; TUMOR-SUPPRESSOR ; PROMOTES APOPTOSIS ; TEAD/TEF FAMILY ; PROTEIN-KINASE ; HUMAN CANCER ; YAP PATHWAY ; DROSOPHILA |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2123 |
| Collection | 生命科学与技术学院_特聘教授组_赵允组 生命科学与技术学院_特聘教授组_张雷组 |
| Corresponding Author | Zhang, Lei |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Cell Biol, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Dong, Liang,Li, Jinhui,Huang, Hongling,et al. Growth suppressor lingerer regulates bantam microRNA to restrict organ size[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(5):415-428. |
| APA | Dong, Liang.,Li, Jinhui.,Huang, Hongling.,Yin, Meng-Xin.,Xu, Jinjin.,...&Zhang, Lei.(2015).Growth suppressor lingerer regulates bantam microRNA to restrict organ size.JOURNAL OF MOLECULAR CELL BIOLOGY,7(5),415-428. |
| MLA | Dong, Liang,et al."Growth suppressor lingerer regulates bantam microRNA to restrict organ size".JOURNAL OF MOLECULAR CELL BIOLOGY 7.5(2015):415-428. |
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