Growth suppressor lingerer regulates bantam microRNA to restrict organ size

doi:10.1093/jmcb/mjv045

	Growth suppressor lingerer regulates bantam microRNA to restrict organ size
	Dong, Liang 1; Li, Jinhui 1; Huang, Hongling 1; Yin, Meng-Xin 1; Xu, Jinjin 1; Li, Peixue 1; Lu, Yi 1; Wu, Wenqing 1; Yang, Hang 2; Zhao, Yun1,3 ; Zhang, Lei1,3
	2015-10
发表期刊	JOURNAL OF MOLECULAR CELL BIOLOGY
ISSN	1674-2788
卷号	7 期号:5 页码:415-428
发表状态	已发表
DOI	10.1093/jmcb/mjv045
摘要	The evolutionarily conserved Hippo signaling pathway plays an important role in organ size control by regulating cell proliferation and apoptosis. Here, we identify Lingerer (Lig) as a growth suppressor using RNAi modifying screen in Drosophila melanogaster. Loss of lig increases organ size and upregulates bantam (ban) and the expression of the Hippo pathway target genes, while overexpression of lig results in diminished ban expression and organ size reduction. We demonstrate that Lig C-terminal exhibits dominant-negative function on growth and ban expression, and thus plays an important role in organ size control and ban regulation. In addition, we provide evidence that both Yki and Mad are essential for Lig-induced ban expression. We also show that Lig regulates the expression of the Hippo pathway target genes partially via Yorkie. Moreover, we find that Lig physically interacts with and requires Salvador to restrict cell growth. Taken together, we demonstrate that Lig functions as a critical growth suppressor to control organ size via ban and Hippo signaling.
关键词	lingerer Hippo Salvador Yorkie Mad organ size control bantam
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31171394] ; National Natural Science Foundation of China[31371462]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000363201800004
出版者	OXFORD UNIV PRESS
WOS关键词	HIPPO SIGNALING PATHWAY ; CONTROLS TISSUE-GROWTH ; CELL-CYCLE EXIT ; TUMOR-SUPPRESSOR ; PROMOTES APOPTOSIS ; TEAD/TEF FAMILY ; PROTEIN-KINASE ; HUMAN CANCER ; YAP PATHWAY ; DROSOPHILA
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2123
专题	生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Zhang, Lei
作者单位	1.Chinese Acad Sci, State Key Lab Cell Biol, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Dong, Liang,Li, Jinhui,Huang, Hongling,et al. Growth suppressor lingerer regulates bantam microRNA to restrict organ size[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015,7(5):415-428.
APA	Dong, Liang.,Li, Jinhui.,Huang, Hongling.,Yin, Meng-Xin.,Xu, Jinjin.,...&Zhang, Lei.(2015).Growth suppressor lingerer regulates bantam microRNA to restrict organ size.JOURNAL OF MOLECULAR CELL BIOLOGY,7(5),415-428.
MLA	Dong, Liang,et al."Growth suppressor lingerer regulates bantam microRNA to restrict organ size".JOURNAL OF MOLECULAR CELL BIOLOGY 7.5(2015):415-428.