Splicing noncoding RNAs from the inside out

doi:10.1002/wrna.1307

	Splicing noncoding RNAs from the inside out
	Yang, Li1,2,3
	2015-11-01
发表期刊	WILEY INTERDISCIPLINARY REVIEWS-RNA
ISSN	1757-7004
卷号	6 期号:6 页码:651-660
发表状态	已发表
DOI	10.1002/wrna.1307
摘要	Eukaryotic precursor-messenger RNAs (pre-mRNAs) undergo splicing to remove intragenic regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature messenger RNAs (mRNAs) that are used for translation, introns that are spliced out of pre-mRNAs were generally believed to lack function and to be degraded. However, recent studies have revealed that a large group of spliced introns can escape complete degradation and are processed to generate noncoding RNAs (ncRNAs), including different types of small RNAs, long-noncoding RNAs, and circular RNAs. Strikingly, exonic sequences can be also back-spliced from pre-mRNAs to form stable circular RNAs. Together, the findings that ncRNAs can be spliced out of mRNA precursors not only expand the ever-growing repertoire of ncRNAs that originate from different genomic regions, but also reveal the unexpected transcriptomic complexity and functional capacity of eukaryotic genomes. WIREs RNA 2015, 6:651-660. doi: 10.1002/wrna.1307 For further resources related to this article, please visit the .
收录类别	SCI
语种	英语
资助项目	MOST[2014CB910600]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000363871000004
出版者	WILEY
WOS关键词	SMALL NUCLEOLAR RNA ; CIRCULAR RNAS ; INTERVENING SEQUENCE ; BIOGENESIS ; MICRORNAS ; INTRON ; GENES ; REVEALS ; HOST ; IDENTIFICATION
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2102
专题	生命科学与技术学院_特聘教授组_杨力组
通讯作者	Yang, Li
作者单位	1.CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Li. Splicing noncoding RNAs from the inside out[J]. WILEY INTERDISCIPLINARY REVIEWS-RNA,2015,6(6):651-660.
APA	Yang, Li.(2015).Splicing noncoding RNAs from the inside out.WILEY INTERDISCIPLINARY REVIEWS-RNA,6(6),651-660.
MLA	Yang, Li."Splicing noncoding RNAs from the inside out".WILEY INTERDISCIPLINARY REVIEWS-RNA 6.6(2015):651-660.