Agonist antibody that induces human malignant cells to kill one another

doi:10.1073/pnas.1519079112

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	Agonist antibody that induces human malignant cells to kill one another
	Yea, Kyungmoo1 ; Zhang, Hongkai 2; Xie, Jia 2; Jones, Teresa M.2; Lin, Chih-Wei 2; Francesconi, Walter 3; Berton, Fulvia 4; Fallahi, Mohammad 5; Sauer, Karsten 2,6; Lerner, Richard A.2
	2015-11-10
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (IF:9.4[JCR-2023],10.8[5-Year])
ISSN	0027-8424
卷号	112 期号:45 页码:E6158-E6165
发表状态	已发表
DOI	10.1073/pnas.1519079112
摘要	An attractive, but as yet generally unrealized, approach to cancer therapy concerns discovering agents that change the state of differentiation of the cancer cells. Recently, we discovered a phenomenon that we call "receptor pleiotropism" in which agonist antibodies against known receptors induce cell fates that are very different from those induced by the natural agonist to the same receptor. Here, we show that one can take advantage of this phenomenon to convert acute myeloblastic leukemic cells into natural killer cells. Upon induction with the antibody, these leukemic cells enter into a differentiation cascade in which as many as 80% of the starting leukemic cells can be differentiated. The antibody-induced killer cells make large amounts of perforin, IFN-gamma, and granzyme B and attack and kill other members of the leukemic cell population. Importantly, induction of killer cells is confined to transformed cells, in that normal bone marrow cells are not induced to form killer cells. Thus, it seems possible to use agonist antibodies to change the differentiation state of cancer cells into those that attack and kill other members of the malignant clone from which they originate.
关键词	agonist antibody natural killer cell differentiation combinatorial antibody libraries
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000364470300013
出版者	NATL ACAD SCIENCES
WOS关键词	INTRACELLULAR COMBINATORIAL LIBRARIES ; H-2-DEFICIENT LYMPHOMA VARIANTS ; ACUTE PROMYELOCYTIC LEUKEMIA ; DENDRITIC CELLS ; STEM-CELLS ; T-CELLS ; CANCER ; SELECTION ; EXPRESSION ; RECEPTORS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2092
专题	免疫化学研究所免疫化学研究所_特聘教授组_抗体设计学实验室
通讯作者	Lerner, Richard A.
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunol Studies, Shanghai 200031, Peoples R China 2.Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA 3.Scripps Res Inst, Dept Mol & Cellular Neurosci, La Jolla, CA 92037 USA 4.Scripps Res Inst, Dept Chem Physiol, La Jolla, CA 92037 USA 5.Scripps Florida, Scripps Res Inst, Bioinformat Core, Jupiter, FL 33458 USA 6.Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
第一作者单位	上海科技大学
第一作者的第一单位	上海科技大学
推荐引用方式 GB/T 7714	Yea, Kyungmoo,Zhang, Hongkai,Xie, Jia,et al. Agonist antibody that induces human malignant cells to kill one another[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(45):E6158-E6165.
APA	Yea, Kyungmoo.,Zhang, Hongkai.,Xie, Jia.,Jones, Teresa M..,Lin, Chih-Wei.,...&Lerner, Richard A..(2015).Agonist antibody that induces human malignant cells to kill one another.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(45),E6158-E6165.
MLA	Yea, Kyungmoo,et al."Agonist antibody that induces human malignant cells to kill one another".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.45(2015):E6158-E6165.