Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling

doi:10.1016/j.stemcr.2015.09.019

	Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling
	Yang, Rong 1; Wang, Minglei 1; Wang, Jia 1; Huang, Xingxu2 ; Yang, Ru 1; Gao, Wei-Qiang 1,3
	2015-11-10
发表期刊	STEM CELL REPORTS (IF:5.9[JCR-2023],5.9[5-Year])
ISSN	2213-6711
卷号	5 期号:5 页码:816-828
发表状态	已发表
DOI	10.1016/j.stemcr.2015.09.019
摘要	Symmetric and asymmetric divisions are important for self-renewal and differentiation of stem cells during neurogenesis. Although cerebellar granule neurogenesis is controlled by sonic hedgehog (SHH) signaling, whether and how this process is mediated by regulation of cell division modes have not been determined. Here, using time-lapse imaging and cell culture from neuronal progenitor-specific and differentiated neuron-specific reporter mouse lines (Math1-GFP and Dcx-DsRed) and Patched(+/-) mice in which SHH signaling is activated, we find evidence for the existence of symmetric and asymmetric divisions that are closely associated with progenitor proliferation and differentiation. While activation of the SHH pathway enhances symmetric progenitor cell divisions, blockade of the SHH pathway reverses the cell division mode change in Math1-GFP; Dcx-DsRed; Patched(+/-) mice by promoting asymmetric divisions or terminal neuronal symmetric divisions. Thus, cell division mode change mediates the regulation of cerebellar granule neurogenesis controlled by SHH signaling.
收录类别	SCI
语种	英语
资助项目	Shanghai Education Committee Key Discipline and Specialty Foundation[J50208]
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000364991000013
出版者	CELL PRESS
WOS关键词	DEVELOPING NERVOUS-SYSTEM ; MICROTUBULE-ASSOCIATED PROTEIN ; NEURAL PROGENITORS ; PRONEURAL GENE ; NEURONS ; MEDULLOBLASTOMA ; DROSOPHILA ; MICE ; DIFFERENTIATION ; NEOCORTEX
原始文献类型	Article
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2091
专题	生命科学与技术学院_PI研究组_黄行许组生物医学工程学院
通讯作者	Yang, Ru
作者单位	1.Shanghai Jiao Tong Univ, Sch Biomed Engn, Renji MedX Stem Cell Res Ctr, State Key Lab Oncogenes & Related Genes,Ren Ji Ho, Shanghai 200030, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Collaborat Innovat Ctr Syst Biomed, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Yang, Rong,Wang, Minglei,Wang, Jia,et al. Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling[J]. STEM CELL REPORTS,2015,5(5):816-828.
APA	Yang, Rong,Wang, Minglei,Wang, Jia,Huang, Xingxu,Yang, Ru,&Gao, Wei-Qiang.(2015).Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling.STEM CELL REPORTS,5(5),816-828.
MLA	Yang, Rong,et al."Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling".STEM CELL REPORTS 5.5(2015):816-828.