Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism

doi:10.1007/s12274-017-1905-8

	Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism
	Wang, Lu 1,2; Wang, Zejun 1,2; Li, Xiaoming3 ; Zhang, Yi 1,2; Yin, Min 1,2; Li, Jiang 1,2; Song, Haiyun 4; Shi, Jiye 1,2,5; Ling, Daishun 6; Wang, Lihua 1,2; Chen, Nan 1,2; Fan, Chunhai1,2,3
	2018-05
发表期刊	NANO RESEARCH
ISSN	1998-0124
卷号	11 期号:5 页码:2746-2755
发表状态	已发表
DOI	10.1007/s12274-017-1905-8
摘要	Magnetite nanoparticles (Fe3O4 NPs) are a well proven biocompatible nanomaterial, which hold great promise in various biomedical applications. Interestingly, unlike conventional biocompatible materials (e.g., polyethylene glycol (PEG)) that are chemically and biologically inert in nature, Fe3O4 NPs are known to be catalytically active and exhibit prominent physiological effects. Herein, we report an "active", dynamic equilibrium mechanism for maintaining the cellular amenity of Fe3O4 NPs. We examined the effects of two types of iron oxide (magnetite and hematite) NPs in rat pheochromocytoma (PC12) cells and found that both induced stress responses. However, only Fe2O3 NPs caused significant programmed cell death; whereas Fe3O4 NPs are amenable to cells. We found that intrinsic catalase-like activity of Fe3O4 NPs antagonized the accumulation of toxic reactive oxygen species (ROS) induced by themselves, and thereby modulated the extent of cellular oxidative stress, autophagic activity, and programmed cell death. In line with this observation, we effectively reversed severe autophagy and cell death caused by Fe2O3 NPs via co-treatment with natural catalase. This study not only deciphers the distinct intrinsic antagonism of Fe3O4 NPs, but opens new routes to designing biocompatible theranostic nanoparticles with novel mechanisms.
关键词	catalase-like activity iron oxide nanoparticles autophagy cytotoxicity reactive oxygen species
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH019] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH031]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000431999700039
出版者	TSINGHUA UNIV PRESS
WOS关键词	MESENCHYMAL STEM-CELLS ; MAGNETIC NANOPARTICLES ; INDUCED AUTOPHAGY ; OXIDATIVE STRESS ; CANCER-CELLS ; IN-VITRO ; CYTOTOXICITY ; APOPTOSIS ; GRAPHENE ; THERAPY
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20878
专题	生命科学与技术学院_公共科研平台_分子影像平台生命科学与技术学院_特聘教授组_樊春海组
通讯作者	Chen, Nan; Fan, Chunhai
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China 5.UCB Pharma, 208 Bath Rd, Slough SL1 3WE, Berks, England 6.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Lu,Wang, Zejun,Li, Xiaoming,et al. Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism[J]. NANO RESEARCH,2018,11(5):2746-2755.
APA	Wang, Lu.,Wang, Zejun.,Li, Xiaoming.,Zhang, Yi.,Yin, Min.,...&Fan, Chunhai.(2018).Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism.NANO RESEARCH,11(5),2746-2755.
MLA	Wang, Lu,et al."Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism".NANO RESEARCH 11.5(2018):2746-2755.