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FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1
2015-12-29
发表期刊CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN2211-1247
卷号13期号:12页码:2794-2807
发表状态已发表
DOI10.1016/j.celrep.2015.11.057
摘要Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation. We report that the Fmr1-encoded protein, FMRP-mediated axonal delivery of miR-181d negatively regulates axon elongation by locally targeting the transcripts of MAP1B (Map1b) and calmodulin (Calm1) in primary sensory neurons. miR-181d affected the local synthesis of MAP1B and calmodulin in axons. FMRP was associated with miR-181d, Map1b, and Calm1. Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons. Furthermore, nerve growth factor (NGF) induced Map1b and Calm1 release from FMRP and miR-181d-repressing granules, thereby promoting axon elongation. Both miR-181d overexpression and FMRP knockdown impaired NGF-induced axon elongation. Our study reveals a mechanism for the local regulation of translation by miR-181d and FMRP during axon development.
收录类别SCI
语种英语
资助项目Shanghai Postdoctoral Science Foundation[12R21417300]
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000367331200014
出版者CELL PRESS
WOS关键词MESSENGER-RNA ; PROTEIN ; TRANSLATION ; MICRORNAS ; NGF ; LOCALIZATION ; EXPRESSION ; TRANSPORT ; SURVIVAL ; GROWTH
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2068
专题生命科学与技术学院_特聘教授组_张旭组
生命科学与技术学院_特聘教授组_鲍岚组
通讯作者Bao, Lan
作者单位
1.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci,Inst Biochem & Ce, Shanghai 200031, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位生命科学与技术学院
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GB/T 7714
Wang, Bin,Pan, Lin,Wei, Manyi,et al. FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1[J]. CELL REPORTS,2015,13(12):2794-2807.
APA Wang, Bin.,Pan, Lin.,Wei, Manyi.,Wang, Qiong.,Liu, Wen-Wen.,...&Bao, Lan.(2015).FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1.CELL REPORTS,13(12),2794-2807.
MLA Wang, Bin,et al."FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1".CELL REPORTS 13.12(2015):2794-2807.
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