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ShanghaiTech University Knowledge Management System
FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1 | |
2015-12-29 | |
发表期刊 | CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year]) |
ISSN | 2211-1247 |
卷号 | 13期号:12页码:2794-2807 |
发表状态 | 已发表 |
DOI | 10.1016/j.celrep.2015.11.057 |
摘要 | Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation. We report that the Fmr1-encoded protein, FMRP-mediated axonal delivery of miR-181d negatively regulates axon elongation by locally targeting the transcripts of MAP1B (Map1b) and calmodulin (Calm1) in primary sensory neurons. miR-181d affected the local synthesis of MAP1B and calmodulin in axons. FMRP was associated with miR-181d, Map1b, and Calm1. Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons. Furthermore, nerve growth factor (NGF) induced Map1b and Calm1 release from FMRP and miR-181d-repressing granules, thereby promoting axon elongation. Both miR-181d overexpression and FMRP knockdown impaired NGF-induced axon elongation. Our study reveals a mechanism for the local regulation of translation by miR-181d and FMRP during axon development. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Shanghai Postdoctoral Science Foundation[12R21417300] |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000367331200014 |
出版者 | CELL PRESS |
WOS关键词 | MESSENGER-RNA ; PROTEIN ; TRANSLATION ; MICRORNAS ; NGF ; LOCALIZATION ; EXPRESSION ; TRANSPORT ; SURVIVAL ; GROWTH |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2068 |
专题 | 生命科学与技术学院_特聘教授组_张旭组 生命科学与技术学院_特聘教授组_鲍岚组 |
通讯作者 | Bao, Lan |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci,Inst Biochem & Ce, Shanghai 200031, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Wang, Bin,Pan, Lin,Wei, Manyi,et al. FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1[J]. CELL REPORTS,2015,13(12):2794-2807. |
APA | Wang, Bin.,Pan, Lin.,Wei, Manyi.,Wang, Qiong.,Liu, Wen-Wen.,...&Bao, Lan.(2015).FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1.CELL REPORTS,13(12),2794-2807. |
MLA | Wang, Bin,et al."FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1".CELL REPORTS 13.12(2015):2794-2807. |
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