Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types

doi:10.1038/ncomms10499

	Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types
	Wang, Cheng 1,2; Gu, Yayun 1,2; Zhang, Kai 1,2; Xie, Kaipeng 1,2; Zhu, Meng 1,2; Dai, Ningbin 1,2; Jiang, Yue 1,2; Guo, Xuejiang 1; Liu, Mingxi 1; Dai, Juncheng 1,2; Wu, Linxiang 3; Jin, Guangfu 1,2; Ma, Hongxia 1,2; Jiang, Tao 1,2; Yin, Rong 4; Xia, Yankai 5; Liu, Li 6; Wang, Shouyu 5; Shen, Bin 1; Huo, Ran 1; Wang, Qianghu 3; Xu, Lin 4; Yang, Liuqing 7; Huang, Xingxu8 ; Shen, Hongbing 1,2; Sha, Jiahao 1; Hu, Zhibin 1,2
	2016-01
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN	2041-1723
卷号	7
发表状态	已发表
DOI	10.1038/ncomms10499
摘要	Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern can help identify driver genes in cancer. In this study, we integrate transcriptomics data from multiple databases and systematically identify 876 new CT genes in 19 cancer types. We explore their relationship with testis-specific regulatory elements. We propose that extremely highly expressed CTgenes (EECTGs) are potential drivers activated through epigenetic mechanisms. We find mutually exclusive associations between EECTGs and somatic mutations in mutated genes, such as PIK3CA in breast cancer. We also provide evidence that promoter demethylation and close non-coding RNAs (namely, CT-ncRNAs) may be two mechanisms to reactivate EECTG gene expression. We show that the meiosis-related EECTG (MEIOB) and its nearby CT-ncRNA have a role in tumorigenesis in lung adenocarcinoma. Our findings provide methods for identifying epigenetic-driver genes of cancer, which could serve as targets of future cancer therapies.
收录类别	SCI
语种	英语
资助项目	National Science Foundation for Distinguished Young Scholars of China[81225020]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000369024100001
出版者	NATURE PUBLISHING GROUP
WOS关键词	CANCER/TESTIS ANTIGENS ; RNA-SEQ ; GENOME ; LUNG ; RECOMBINATION ; IMMUNOTHERAPY ; LANDSCAPE ; DRIVER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2051
专题	生命科学与技术学院_PI研究组_黄行许组
通讯作者	Shen, Hongbing; Sha, Jiahao; Hu, Zhibin
作者单位	1.Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China 2.Nanjing Med Univ, Sch Publ Hlth,Dept Epidemol & Biostat, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210029, Jiangsu, Peoples R China 3.Nanjing Med Univ, Sch Basic Med Sci, Dept Bioinformat, Nanjing 210029, Jiangsu, Peoples R China 4.Nanjing Med Univ, Affiliated Canc Hosp, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Mol & Translat Canc Res, Nanjing 210009, Jiangsu, Peoples R China 5.Nanjing Med Univ, Sch Publ Hlth,Dept Mol Cell Biol & Toxicol, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210029, Jiangsu, Peoples R China 6.Nanjing Med Univ, Affiliated Hosp 1, Digest Endoscopy Ctr, Nanjing 210029, Jiangsu, Peoples R China 7.Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Non Coding RNAs, Canc Biol Program, Dept Mol & Cellular Oncol, Houston, TX 77030 USA 8.Shanghai Tech Univ, Sch Life Sci & Technol, Pudong New Area, 100 Haike Rd, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Wang, Cheng,Gu, Yayun,Zhang, Kai,et al. Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types[J]. NATURE COMMUNICATIONS,2016,7.
APA	Wang, Cheng.,Gu, Yayun.,Zhang, Kai.,Xie, Kaipeng.,Zhu, Meng.,...&Hu, Zhibin.(2016).Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.NATURE COMMUNICATIONS,7.
MLA	Wang, Cheng,et al."Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types".NATURE COMMUNICATIONS 7(2016).