Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction

doi:10.1007/s11426-016-0103-7

	Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction
	Wang, Lu 1,2; Li, Xiaoming1,2,5 ; Han, Yuping 3; Wang, Ting 3; Zhao, Yun 3; Ali, Aldalbahi 4; El-Sayed, Nahed Nasser 4; Shi, Jiye 6; Wang, Wenfeng 1,2; Fan, Chunhai 1,2; Chen, Nan 1,2
	2016
发表期刊	SCIENCE CHINA-CHEMISTRY (IF:10.4[JCR-2023],7.9[5-Year])
ISSN	1674-7291
卷号	59 期号:11 页码:1486-1491
发表状态	已发表
DOI	10.1007/s11426-016-0103-7
摘要	Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson's disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of alpha-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.
关键词	quantum dots autophagy Parkinson's disease alpha-Synuclein Beclin1
收录类别	SCI ; EI
语种	英语
资助项目	Shanghai Municipal Commission for Science and Technology[13NM1402300]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000387571100016
出版者	SCIENCE PRESS
EI入藏号	20164302942258
EI主题词	Cell death ; Disease control ; Nanocrystals ; Neurodegenerative diseases ; Proteins
WOS关键词	EUROPIUM HYDROXIDE NANORODS ; NEURODEGENERATIVE DISEASES ; CLEARANCE ; NANOPARTICLES ; CYTOTOXICITY ; NANOCRYSTALS ; MECHANISMS ; PATHWAYS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1994
专题	生命科学与技术学院_公共科研平台_分子影像平台
通讯作者	Zhao, Yun; Chen, Nan
作者单位	1.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 3.Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China 4.King Saud Univ, Dept Chem, Riyadh 11451, Saudi Arabia 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.UCB Pharma, Slough SL1 3WE, Berks, England
推荐引用方式 GB/T 7714	Wang, Lu,Li, Xiaoming,Han, Yuping,et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction[J]. SCIENCE CHINA-CHEMISTRY,2016,59(11):1486-1491.
APA	Wang, Lu.,Li, Xiaoming.,Han, Yuping.,Wang, Ting.,Zhao, Yun.,...&Chen, Nan.(2016).Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction.SCIENCE CHINA-CHEMISTRY,59(11),1486-1491.
MLA	Wang, Lu,et al."Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction".SCIENCE CHINA-CHEMISTRY 59.11(2016):1486-1491.