Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction
Wang, Lu1,2; Li, Xiaoming1,2,5; Han, Yuping3; Wang, Ting3; Zhao, Yun3; Ali, Aldalbahi4; El-Sayed, Nahed Nasser4; Shi, Jiye6; Wang, Wenfeng1,2; Fan, Chunhai1,2
2016
发表期刊SCIENCE CHINA-CHEMISTRY
ISSN1674-7291
卷号59期号:11页码:1486-1491
发表状态已发表
DOI10.1007/s11426-016-0103-7
摘要Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson's disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of alpha-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.
关键词quantum dots autophagy Parkinson's disease alpha-Synuclein Beclin1
收录类别SCI ; EI
语种英语
资助项目Shanghai Municipal Commission for Science and Technology[13NM1402300]
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000387571100016
出版者SCIENCE PRESS
EI入藏号20164302942258
EI主题词Cell death ; Disease control ; Nanocrystals ; Neurodegenerative diseases ; Proteins
WOS关键词EUROPIUM HYDROXIDE NANORODS ; NEURODEGENERATIVE DISEASES ; CLEARANCE ; NANOPARTICLES ; CYTOTOXICITY ; NANOCRYSTALS ; MECHANISMS ; PATHWAYS
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1994
专题生命科学与技术学院_公共科研平台_分子影像平台
通讯作者Zhao, Yun; Chen, Nan
作者单位1.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
3.Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China
4.King Saud Univ, Dept Chem, Riyadh 11451, Saudi Arabia
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
6.UCB Pharma, Slough SL1 3WE, Berks, England
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Wang, Lu,Li, Xiaoming,Han, Yuping,et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction[J]. SCIENCE CHINA-CHEMISTRY,2016,59(11):1486-1491.
APA Wang, Lu.,Li, Xiaoming.,Han, Yuping.,Wang, Ting.,Zhao, Yun.,...&Chen, Nan.(2016).Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction.SCIENCE CHINA-CHEMISTRY,59(11),1486-1491.
MLA Wang, Lu,et al."Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction".SCIENCE CHINA-CHEMISTRY 59.11(2016):1486-1491.
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