Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread

doi:10.1038/s41467-022-30415-3

	Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread
	Zhang, Xiaokang 1,2; Cui, Mengkui3 ; Wang, Shuoshuo 1,2; Han, Fei 4; Xu, Pingping 1,2; Teng, Luyao 1,2; Zhao, Hang 4; Wang, Ping 4; Yue, Guichu 5; Zhao, Yong 5; Liu, Guangfeng 6; Li, Ke3 ; Zhang, Jicong3 ; Liang, Xiaoping 7; Zhang, Yingying 7; Liu, Zhiyuan 4; Zhong, Chao 8,9; Liu, Weizhi 1,2
	2022-05-18
发表期刊	NATURE COMMUNICATION
ISSN	20411723
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-30415-3
摘要	Biologically derived and biologically inspired fibers with outstanding mechanical properties have found attractive technical applications across diverse fields. Despite recent advances, few fibers can simultaneously possess high-extensibility and self-recovery properties especially under wet conditions. Here, we report protein-based fibers made from recombinant scallop byssal proteins with outstanding extensibility and self-recovery properties. We initially investigated the mechanical properties of the native byssal thread taken from scallop Chlamys farreri and reveal its high extensibility (327 ± 32%) that outperforms most natural biological fibers. Combining transcriptome and proteomics, we select the most abundant scallop byssal protein type 5-2 (Sbp5-2) in the thread region, and produce a recombinant protein consisting of 7 tandem repeat motifs (rTRM7) of the Sbp5-2 protein. Applying an organic solvent-enabled drawing process, we produce bio-inspired extensible rTRM7 fiber with high-extensibility (234 ± 35%) and self-recovery capability in wet condition, recapitulating the hierarchical structure and mechanical properties of the native scallop byssal thread. We further show that the mechanical properties of rTRM7 fiber are highly regulated by hydrogen bonding and intermolecular crosslinking formed through disulfide bond and metal-carboxyl coordination. With its outstanding mechanical properties, rTRM7 fiber can also be seamlessly integrated with graphene to create motion sensors and electrophysiological signal transmission electrode.
关键词	Biomaterials, Biopolymers in vivo, Biosynthesis, Proteins
学科门类	工学::材料科学与工程（可授工学、理学学位）
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
Scopus 记录号	2-s2.0-85130224475
来源库	Scopus
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/197865
专题	物质科学与技术学院_博士生
通讯作者	Liu, Zhiyuan; Zhong, Chao; Liu, Weizhi
作者单位	1.Sars-Fang Centre,MOE Key Laboratory of Marine Genetics and Breeding,College of Marine Life Sciences,Ocean University of China,Qingdao,266003,China 2.Laboratory for Marine Biology and Biotechnology,Pilot National Laboratory for Marine Science and Technology,Qingdao,266071,China 3.Materials and Physical Biology Division,School of Physical Science and Technology,ShanghaiTech University,Shanghai,201210,China 4.Neural Engineering Centre,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China 5.School of Chemistry,Beihang University,Beijing,100191,China 6.National Center for Protein Science Shanghai,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201204,China 7.Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education,Department of Chemistry and Center for Nano and Micro Mechanics,Tsinghua University,Beijing,100084,China 8.Center for Materials Synthetic Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China 9.CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
推荐引用方式 GB/T 7714	Zhang, Xiaokang,Cui, Mengkui,Wang, Shuoshuo,et al. Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread[J]. NATURE COMMUNICATION,2022,13(1).
APA	Zhang, Xiaokang.,Cui, Mengkui.,Wang, Shuoshuo.,Han, Fei.,Xu, Pingping.,...&Liu, Weizhi.(2022).Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread.NATURE COMMUNICATION,13(1).
MLA	Zhang, Xiaokang,et al."Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread".NATURE COMMUNICATION 13.1(2022).