Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription

doi:10.1038/srep18937

	Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription
	Han, Hui 1; Fan, Jialin 1; Xiong, Yue 1; Wu, Wenqing 1; Lu, Yi 1; Zhang, Lei1,2 ; Zhao, Yun1,2
	2016-01-07
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6
发表状态	已发表
DOI	10.1038/srep18937
摘要	Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential to the same process. It has been reported that Ap and Chi function as a tetramer to regulate Notch signaling. At the same time, dLMO (the protein product of gene bx) regulates the activity of Ap by competing its binding with Chi. However, the detailed functions of Chi and dLMO on Notch signaling and the relevant mechanisms remain largely unknown. Here, we report the detailed functions of Chi and dLMO on Notch signaling. Different Chi protein levels in adjacent cells could activate Notch signaling mainly in the cells with higher level of Chi. dLMO could induce antagonistical phenotypes on Notch signaling compared to that induced by Chi. These processes depend on their direct regulation of fringe (fng) transcription.
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31171414] ; National Natural Science Foundation of China[31371492]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000368193400001
出版者	NATURE PUBLISHING GROUP
WOS关键词	DROSOPHILA WING DEVELOPMENT ; LIM-HOMEODOMAIN ACTIVITY ; IN-VIVO ; APTEROUS ACTIVITY ; IMAGINAL DISC ; VENTRAL CELLS ; FRINGE ; COMPLEX ; GLYCOSYLTRANSFERASE ; EXPRESSION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1949
专题	生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Zhao, Yun
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Innovat Ctr Cell Signaling Network,Inst Biol Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Han, Hui,Fan, Jialin,Xiong, Yue,et al. Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription[J]. SCIENTIFIC REPORTS,2016,6.
APA	Han, Hui.,Fan, Jialin.,Xiong, Yue.,Wu, Wenqing.,Lu, Yi.,...&Zhao, Yun.(2016).Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.SCIENTIFIC REPORTS,6.
MLA	Han, Hui,et al."Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription".SCIENTIFIC REPORTS 6(2016).