DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo
Li, Meng-yuan1,2,4; Lv, Yong-cong3; Tong, Lin-jiang2; Peng, Ting2; Qu, Rong2,4; Zhang, Tao4,5; Sun, Yi-ming2; Chen, Yi2; Wei, Li-xin1,4; Geng, Mei-yu2; Duan, Wen-hu3; Xie, Hua2; Ding, Jian2
2016-03
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume37Issue:3Pages:398-407
Status已发表
DOI10.1038/aps.2015.117
Abstract

Aim: Targeting the VEGF/VEGF receptor (VEGFR) pathway has proved to be an effective antiangiogenic approach for cancer treatment. Here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-N-phenyl-1-naphthamide (designated herein as DW10075) as a novel and highly selective inhibitor of VEGFRs.

KeywordDW10075 VEGF/VEGF receptor inhibitor antitumor angiogenesis U87-MG human glioblastoma
Indexed BySCI
Funding ProjectResearch Program of Qinghai province[2012-T-Y23]
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000371426900012
PublisherACTA PHARMACOLOGICA SINICA
WOS KeywordMETASTATIC COLORECTAL-CANCER ; RENAL-CELL CARCINOMA ; ANGIOGENESIS INHIBITORS ; BEVACIZUMAB ; AXITINIB ; TARGETS ; KINASES ; POTENT
Original Document TypeArticle
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1914
Collection生命科学与技术学院_特聘教授组_耿美玉组
生命科学与技术学院_特聘教授组_丁健组
Corresponding AuthorDuan, Wen-hu; Xie, Hua; Ding, Jian
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810008, Peoples R China
2.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Shanghai Tech Univ, Shanghai 200120, Peoples R China
Recommended Citation
GB/T 7714
Li, Meng-yuan,Lv, Yong-cong,Tong, Lin-jiang,et al. DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo[J]. ACTA PHARMACOLOGICA SINICA,2016,37(3):398-407.
APA Li, Meng-yuan.,Lv, Yong-cong.,Tong, Lin-jiang.,Peng, Ting.,Qu, Rong.,...&Ding, Jian.(2016).DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.ACTA PHARMACOLOGICA SINICA,37(3),398-407.
MLA Li, Meng-yuan,et al."DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo".ACTA PHARMACOLOGICA SINICA 37.3(2016):398-407.
Files in This Item: Download All
File Name/Size DocType Version Access License
10.1038@aps.2015.117(2640KB)期刊论文出版稿开放获取UnknownView Download
Related Services
Usage statistics
Scholar Google
Similar articles in Scholar Google
[Li, Meng-yuan]'s Articles
[Lv, Yong-cong]'s Articles
[Tong, Lin-jiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Meng-yuan]'s Articles
[Lv, Yong-cong]'s Articles
[Tong, Lin-jiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Meng-yuan]'s Articles
[Lv, Yong-cong]'s Articles
[Tong, Lin-jiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.1038@aps.2015.117.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.