Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions

doi:10.7554/eLife.11008

	Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions
	Dong, Xintong 1,2; Chiu, Hui 3,5; Park, Yeonhee Jenny 4; Zou, Wei 1,2; Zou, Yan3,6 ; Ozkan, Engin 4; Chang, Chieh 3; Shen, Kang 1,2
	2016-03-14
发表期刊	ELIFE
ISSN	2050-084X
卷号	5
发表状态	已发表
DOI	10.7554/eLife.11008
摘要	Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis.
收录类别	SCI
语种	英语
资助项目	National Institutes of Health[1R01NS082208-01A1] ; National Institutes of Health[5R01GM111320]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000373896000001
出版者	ELIFE SCIENCES PUBLICATIONS LTD
WOS关键词	CAENORHABDITIS-ELEGANS ; AXON GUIDANCE ; CNS MIDLINE ; C. ELEGANS ; COMMISSURAL AXONS ; SLIT ; DROSOPHILA ; ROBO ; PROTEIN ; SWITCH
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1897
专题	生命科学与技术学院_PI研究组_邹燕组
通讯作者	Chang, Chieh; Shen, Kang
作者单位	1.Stanford Univ, Dept Biol, Stanford, CA 94305 USA 2.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA 3.Univ Illinois, Dept Biol Sci, Chicago, IL 60680 USA 4.Univ Illinois, Dept Biochem & Mol Biol, Chicago, IL USA 5.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA 6.Shanghai Tech Univ, Sch Life Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Dong, Xintong,Chiu, Hui,Park, Yeonhee Jenny,et al. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions[J]. ELIFE,2016,5.
APA	Dong, Xintong.,Chiu, Hui.,Park, Yeonhee Jenny.,Zou, Wei.,Zou, Yan.,...&Shen, Kang.(2016).Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.ELIFE,5.
MLA	Dong, Xintong,et al."Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions".ELIFE 5(2016).