Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions
Dong, Xintong1,2; Chiu, Hui3,5; Park, Yeonhee Jenny4; Zou, Wei1,2; Zou, Yan3,6; Ozkan, Engin4; Chang, Chieh3; Shen, Kang1,2
2016-03-14
发表期刊ELIFE
ISSN2050-084X
卷号5
发表状态已发表
DOI10.7554/eLife.11008
摘要Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis.
收录类别SCI
语种英语
资助项目National Institutes of Health[1R01NS082208-01A1] ; National Institutes of Health[5R01GM111320]
WOS研究方向Life Sciences & Biomedicine - Other Topics
WOS类目Biology
WOS记录号WOS:000373896000001
出版者ELIFE SCIENCES PUBLICATIONS LTD
WOS关键词CAENORHABDITIS-ELEGANS ; AXON GUIDANCE ; CNS MIDLINE ; C. ELEGANS ; COMMISSURAL AXONS ; SLIT ; DROSOPHILA ; ROBO ; PROTEIN ; SWITCH
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1897
专题生命科学与技术学院_PI研究组_邹燕组
通讯作者Chang, Chieh; Shen, Kang
作者单位1.Stanford Univ, Dept Biol, Stanford, CA 94305 USA
2.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
3.Univ Illinois, Dept Biol Sci, Chicago, IL 60680 USA
4.Univ Illinois, Dept Biochem & Mol Biol, Chicago, IL USA
5.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
6.Shanghai Tech Univ, Sch Life Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Dong, Xintong,Chiu, Hui,Park, Yeonhee Jenny,et al. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions[J]. ELIFE,2016,5.
APA Dong, Xintong.,Chiu, Hui.,Park, Yeonhee Jenny.,Zou, Wei.,Zou, Yan.,...&Shen, Kang.(2016).Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.ELIFE,5.
MLA Dong, Xintong,et al."Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions".ELIFE 5(2016).
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