Epigenetic regulation of early neural fate commitment

doi:10.1007/s00018-015-2125-6

	Epigenetic regulation of early neural fate commitment
	Qiao, Yunbo 1; Yang, Xianfa1,2 ; Jing, Naihe1,2
	2016-04
发表期刊	CELLULAR AND MOLECULAR LIFE SCIENCES (IF:6.2[JCR-2023],7.7[5-Year])
ISSN	1420-682X
卷号	73 期号:7 页码:1399-1411
发表状态	已发表
DOI	10.1007/s00018-015-2125-6
摘要	Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by extrinsic signals, intrinsic factors, and epigenetic regulation. Here, we summarize the main findings regarding the regulatory network of epigenetic mechanisms that play important roles during early neural fate determination and embryonic development, including histone modifications, chromatin remodeling, DNA modifications, and RNA-level regulation. These regulatory mechanisms coordinate to play essential roles in silencing of pluripotency genes and activating key neurodevelopmental genes during cell fate commitment at DNA, histone, chromatin, and RNA levels. Moreover, we discuss the relationship between epigenetic regulation, signaling pathways, and intrinsic factors during early neural fate specification.
关键词	Early neural fate commitment Epigenetic regulation Histone modification DNA methylation Chromatin remodeling
收录类别	SCI
语种	英语
资助项目	Chinese Postdoctoral Science Foundation[2013M541560]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000372602900008
出版者	SPRINGER BASEL AG
WOS关键词	LONG NONCODING RNAS ; EMBRYONIC STEM-CELLS ; CHROMATIN REMODELING COMPLEX ; DOUBLE-STRANDED-RNA ; DNA METHYLATION ; MESSENGER-RNA ; DEVELOPMENTAL REGULATORS ; NEURONAL DIFFERENTIATION ; HISTONE DEACETYLATION ; GENE-EXPRESSION
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1884
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_景乃禾组生命科学与技术学院_博士生
通讯作者	Jing, Naihe
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Qiao, Yunbo,Yang, Xianfa,Jing, Naihe. Epigenetic regulation of early neural fate commitment[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2016,73(7):1399-1411.
APA	Qiao, Yunbo,Yang, Xianfa,&Jing, Naihe.(2016).Epigenetic regulation of early neural fate commitment.CELLULAR AND MOLECULAR LIFE SCIENCES,73(7),1399-1411.
MLA	Qiao, Yunbo,et al."Epigenetic regulation of early neural fate commitment".CELLULAR AND MOLECULAR LIFE SCIENCES 73.7(2016):1399-1411.