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ShanghaiTech University Knowledge Management System
Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis | |
2016-04-12 | |
发表期刊 | CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year]) |
ISSN | 2211-1247 |
卷号 | 15期号:2页码:256-263 |
发表状态 | 已发表 |
DOI | 10.1016/j.celrep.2016.03.016 |
摘要 | Uhrf1 (also known as Np95) is a regulator of DNA methylation and histone ubiquitination and plays an important role in embryogenesis and tumorigenesis. Here, we report that Uhrf1 is essential for invariant natural killer T (iNKT) cell development. We found that Uhrf1 was significantly upregulated in stage 1 iNKT cells. Targeted disruption of Uhrf1 resulted in stage 1-specific transition defects as observed by not only increased apoptosis, but also aberrant effector differentiation, which eventually led to the impaired generation of iNKT cells in Uhrf1-deficient mice. Notably, Uhrf1 deficiency resulted in attenuated activation of Akt-mTOR signaling in stage 1 iNKT cells and overexpression of active Akt rescued iNKT cell developmental defects. Collectively, our results suggest that Uhrf1 regulation of the Akt-mTOR signaling pathway is required for iNKT cell development. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[31530021] ; National Natural Science Foundation of China[91542122] |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000374236900005 |
出版者 | CELL PRESS |
WOS关键词 | RAPAMYCIN COMPLEX 1 ; EFFECTOR FUNCTION ; MAMMALIAN TARGET ; NKT CELLS ; FINGER ; ACTIVATION ; PROTEIN |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1870 |
专题 | 生命科学与技术学院_特聘教授组_刘小龙组 |
通讯作者 | Liu, Xiaolong |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Peoples R China 3.Univ Sci & Technol China, Med Ctr, Hefei 230027, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Cui, Yu,Chen, Xufeng,Zhang, Jiali,et al. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis[J]. CELL REPORTS,2016,15(2):256-263. |
APA | Cui, Yu.,Chen, Xufeng.,Zhang, Jiali.,Sun, Xiang.,Liu, Haifeng.,...&Liu, Xiaolong.(2016).Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis.CELL REPORTS,15(2),256-263. |
MLA | Cui, Yu,et al."Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis".CELL REPORTS 15.2(2016):256-263. |
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