Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis

doi:10.1016/j.celrep.2016.03.016

	Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis
	Cui, Yu 1; Chen, Xufeng 1; Zhang, Jiali 1; Sun, Xiang 1; Liu, Haifeng 1; Bai, Li 2,3; Xu, Chenqi 1; Liu, Xiaolong1,4
	2016-04-12
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	15 期号:2 页码:256-263
发表状态	已发表
DOI	10.1016/j.celrep.2016.03.016
摘要	Uhrf1 (also known as Np95) is a regulator of DNA methylation and histone ubiquitination and plays an important role in embryogenesis and tumorigenesis. Here, we report that Uhrf1 is essential for invariant natural killer T (iNKT) cell development. We found that Uhrf1 was significantly upregulated in stage 1 iNKT cells. Targeted disruption of Uhrf1 resulted in stage 1-specific transition defects as observed by not only increased apoptosis, but also aberrant effector differentiation, which eventually led to the impaired generation of iNKT cells in Uhrf1-deficient mice. Notably, Uhrf1 deficiency resulted in attenuated activation of Akt-mTOR signaling in stage 1 iNKT cells and overexpression of active Akt rescued iNKT cell developmental defects. Collectively, our results suggest that Uhrf1 regulation of the Akt-mTOR signaling pathway is required for iNKT cell development.
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31530021] ; National Natural Science Foundation of China[91542122]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000374236900005
出版者	CELL PRESS
WOS关键词	RAPAMYCIN COMPLEX 1 ; EFFECTOR FUNCTION ; MAMMALIAN TARGET ; NKT CELLS ; FINGER ; ACTIVATION ; PROTEIN
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1870
专题	生命科学与技术学院_特聘教授组_刘小龙组
通讯作者	Liu, Xiaolong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Peoples R China 3.Univ Sci & Technol China, Med Ctr, Hefei 230027, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Cui, Yu,Chen, Xufeng,Zhang, Jiali,et al. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis[J]. CELL REPORTS,2016,15(2):256-263.
APA	Cui, Yu.,Chen, Xufeng.,Zhang, Jiali.,Sun, Xiang.,Liu, Haifeng.,...&Liu, Xiaolong.(2016).Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis.CELL REPORTS,15(2),256-263.
MLA	Cui, Yu,et al."Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis".CELL REPORTS 15.2(2016):256-263.