A positive role for polycomb in transcriptional regulation via H4K20me1

doi:10.1038/cr.2016.33

	A positive role for polycomb in transcriptional regulation via H4K20me1
	Lv, Xiangdong 1; Han, Zhijun 2; Chen, Hao 1; Yang, Bo 1; Yang, Xiaofeng 1; Xia, Yuanxin 1; Pan, Chenyu 1; Fu, Lin 1; Zhang, Shuo 1; Han, Hui 1; Wu, Min 3,4; Zhou, Zhaocai 1; Zhang, Lei1,6 ; Li, Lin5,6 ; Wei, Gang 2; Zhao, Yun1,6
	2016-05
发表期刊	CELL RESEARCH
ISSN	1001-0602
卷号	26 期号:5 页码:529-542
发表状态	已发表
DOI	10.1038/cr.2016.33
摘要	The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the underlying mechanism has rarely been reported. Here, we report a Pc-mediated, H3K27me3-dependent positive transcriptional regulation of Senseless (Sens), a key transcription factor required for development. Mechanistic studies show that Pc regulates Sens expression by promoting H4K20me1 at the Sens locus. Further bioinformatic analysis at genome-wide level indicates that the existence of H4K20me1 acts as a selective mark for positive transcriptional regulation by Pc/H3K27me3. Both the intensities and specific patterns of Pc and H3K27me3 are important for the fates of target gene transcription. Moreover, binding of transcription factor Broad (Br), which physically interacts with Pc and positively regulates the transcription of Sens, is observed in Pc+ H3K27me3(+) H4K20me1(+) genes, but not in Pc+ H3K27me3+ H-4K20me1(-) genes. Taken together, our study reveals that, coupling with the transcription factor Br, Pc positively regulates transcription of Pc+ H3K27me3+ H4K20me1(+) genes in developing Drosophila wing disc.
关键词	polycomb group proteins positive transcriptional regulation H3K27me3 H4K20me1 Broad
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[2012OHTP09]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000377449200005
出版者	INST BIOCHEMISTRY & CELL BIOLOGY
WOS关键词	HISTONE METHYLTRANSFERASE ACTIVITY ; EMBRYONIC STEM-CELLS ; GENE-EXPRESSION ; GROUP PROTEINS ; DEVELOPMENTAL REGULATORS ; CHROMATIN-STRUCTURE ; ANALYSIS REVEALS ; SELF-RENEWAL ; CANCER CELLS ; DROSOPHILA
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1851
专题	生命科学与技术学院_特聘教授组_李林组生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Wei, Gang; Zhao, Yun
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Innovat Ctr Cell Signali, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.Wuhan Univ, Coll Life Sci, Dept Biochem & Mol Biol, Wuhan 430072, Hubei, Peoples R China 4.Wuhan Univ, Key Lab Intestinal & Colorectal Dis, Wuhan 430072, Hubei, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Innovat Ctr Cell Signali, State Key Lab Mol Biol,CAS Ctr Excellence Mol Cel, Shanghai 200031, Peoples R China 6.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Lv, Xiangdong,Han, Zhijun,Chen, Hao,et al. A positive role for polycomb in transcriptional regulation via H4K20me1[J]. CELL RESEARCH,2016,26(5):529-542.
APA	Lv, Xiangdong.,Han, Zhijun.,Chen, Hao.,Yang, Bo.,Yang, Xiaofeng.,...&Zhao, Yun.(2016).A positive role for polycomb in transcriptional regulation via H4K20me1.CELL RESEARCH,26(5),529-542.
MLA	Lv, Xiangdong,et al."A positive role for polycomb in transcriptional regulation via H4K20me1".CELL RESEARCH 26.5(2016):529-542.