The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer
Wang, Zifeng1,2; Liu, Na3,4; Shi, Shuo2; Liu, Sanhong2; Lin, Haifan1,2,3,4
2016-05-13
Source PublicationJOURNAL OF BIOLOGICAL CHEMISTRY
ISSN0021-9258
Volume291Issue:20Pages:10646-10658
Status已发表
DOI10.1074/jbc.M116.723239
AbstractP-element-induced wimpy testis (PIWI) proteins bind to PIWI-interacting RNAs and play key roles in the biogenesis and functions of PIWI-interacting RNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms and that they are ectopically expressed in multiple forms of cancer. However, the role of PIWI in cancer remains elusive. Here we report that one of the four PIWI proteins in humans, PIWIL4, is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation. Our transcriptome and proteome analysis reveal that these functions are at least partially achieved via the PIWIL4 regulation of TGF-beta and FGF signaling pathways and MHC class II proteins. These findings suggest that PIWIL4 may serve as a potential therapeutic target for breast cancer.
Indexed BySCI ; EI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000377042600018
PublisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
EI Accession Number20162102415637
EI KeywordsCell death ; Cytology ; Proteins ; Stem cells
EI Classification NumberBiological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Organic Compounds:804.1
WOS KeywordGERMLINE STEM-CELLS ; CLASS-II EXPRESSION ; SMALL RNAS ; INTERACTING RNAS ; GENE-EXPRESSION ; OVARIAN-CANCER ; PIRNA PATHWAY ; SUBTYPES ; SPERMATOGENESIS ; OVEREXPRESSION
Original Document TypeArticle
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1835
Collection免疫化学研究所
生命科学与技术学院
免疫化学研究所_特聘教授组_干细胞生物学实验室
Corresponding AuthorLiu, Sanhong; Lin, Haifan
Affiliation1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
3.Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06520 USA
4.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA
First Author AffilicationSchool of Life Science and Technology;  Shanghai Institute for Advanced Immunochemical Studies
Corresponding Author AffilicationShanghai Institute for Advanced Immunochemical Studies;  School of Life Science and Technology
First Signature AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Wang, Zifeng,Liu, Na,Shi, Shuo,et al. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2016,291(20):10646-10658.
APA Wang, Zifeng,Liu, Na,Shi, Shuo,Liu, Sanhong,&Lin, Haifan.(2016).The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.JOURNAL OF BIOLOGICAL CHEMISTRY,291(20),10646-10658.
MLA Wang, Zifeng,et al."The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer".JOURNAL OF BIOLOGICAL CHEMISTRY 291.20(2016):10646-10658.
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