The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer

doi:10.1074/jbc.M116.723239

KMS > 免疫化学研究所

	The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer
	Wang, Zifeng1,2 ; Liu, Na 3,4; Shi, Shuo2 ; Liu, Sanhong2 ; Lin, Haifan1,2,3,4
	2016-05-13
发表期刊	JOURNAL OF BIOLOGICAL CHEMISTRY
ISSN	0021-9258
卷号	291 期号:20 页码:10646-10658
发表状态	已发表
DOI	10.1074/jbc.M116.723239
摘要	P-element-induced wimpy testis (PIWI) proteins bind to PIWI-interacting RNAs and play key roles in the biogenesis and functions of PIWI-interacting RNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms and that they are ectopically expressed in multiple forms of cancer. However, the role of PIWI in cancer remains elusive. Here we report that one of the four PIWI proteins in humans, PIWIL4, is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation. Our transcriptome and proteome analysis reveal that these functions are at least partially achieved via the PIWIL4 regulation of TGF-beta and FGF signaling pathways and MHC class II proteins. These findings suggest that PIWIL4 may serve as a potential therapeutic target for breast cancer.
收录类别	SCI ; EI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000377042600018
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
EI入藏号	20162102415637
EI主题词	Cell death ; Cytology ; Proteins ; Stem cells
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Organic Compounds:804.1
WOS关键词	GERMLINE STEM-CELLS ; CLASS-II EXPRESSION ; SMALL RNAS ; INTERACTING RNAS ; GENE-EXPRESSION ; OVARIAN-CANCER ; PIRNA PATHWAY ; SUBTYPES ; SPERMATOGENESIS ; OVEREXPRESSION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1835
专题	免疫化学研究所生命科学与技术学院免疫化学研究所_特聘教授组_干细胞生物学实验室
通讯作者	Liu, Sanhong; Lin, Haifan
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 3.Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06520 USA 4.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA
第一作者单位	生命科学与技术学院; 免疫化学研究所
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Zifeng,Liu, Na,Shi, Shuo,et al. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2016,291(20):10646-10658.
APA	Wang, Zifeng,Liu, Na,Shi, Shuo,Liu, Sanhong,&Lin, Haifan.(2016).The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.JOURNAL OF BIOLOGICAL CHEMISTRY,291(20),10646-10658.
MLA	Wang, Zifeng,et al."The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer".JOURNAL OF BIOLOGICAL CHEMISTRY 291.20(2016):10646-10658.