Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases(dagger)

doi:10.1093/biolre/ioac073

	Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases(dagger)
	Wang, Xin 1,2; Gou, Lan-Tao 1; Liu, Mo-Fang1,2,3
	2022-07-25
发表期刊	BIOLOGY OF REPRODUCTION (IF:3.1[JCR-2023],3.7[5-Year])
ISSN	0006-3363
EISSN	1529-7268
发表状态	已发表
DOI	10.1093/biolre/ioac073
摘要	["PIWI proteins and PIWI-interacting RNAs (piRNAs) are specifically expressed in animal germlines and play essential roles during gametogenesis in animals. The primary function of PIWI/piRNAs is known to silence transposable elements for protecting genome integrity in animal germlines, while their roles beyond silencing transposons are also documented by us and others. In particular, we show that mouse PIWIL1 (MIWI)/piRNAs play a dual role in regulating protein-coding genes in mouse spermatids through interacting with different protein factors in a developmental stage-dependent manner, including translationally activating a subset of AU-rich element-containing mRNAs in round spermatids and inducing massive mRNA degradation in late spermatids. We further show that MIWI is eliminated through the ubiquitin-26S proteasome pathway during late spermiogenesis. By exploring the biological function of MIWI ubiquitination by APC/C, we identified ubiquitination-deficient mutations in human PIWIL1 of infertile men and further established their causative role in male infertility in mouse model, supporting PIWIL1 as a human male infertility-relevant gene. Additionally, we reported that PIWIL1, aberrantly induced in human tumors, functions as an oncoprotein in a piRNA-independent manner in cancer cells. In the current review, we summarize our latest findings regarding the roles and mechanisms of PIWIL1 and piRNAs in mouse spermatids and human diseases, and discuss the related works in the field.","Beyond the primary function of silencing transposons, PIWI/piRNAs also play diverse roles in animal germ cells and human diseases."]
关键词	PIWIL1 piRNAs MIWI spermiogenesis male infertility cancer cells
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Reproductive Biology
WOS类目	Reproductive Biology
WOS记录号	WOS:000793014600001
出版者	OXFORD UNIV PRESS INC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/183445
专题	生命科学与技术学院_特聘教授组_刘默芳组
通讯作者	Gou, Lan-Tao; Liu, Mo-Fang
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Hangzhou, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Xin,Gou, Lan-Tao,Liu, Mo-Fang. Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases(dagger)[J]. BIOLOGY OF REPRODUCTION,2022.
APA	Wang, Xin,Gou, Lan-Tao,&Liu, Mo-Fang.(2022).Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases(dagger).BIOLOGY OF REPRODUCTION.
MLA	Wang, Xin,et al."Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases(dagger)".BIOLOGY OF REPRODUCTION (2022).