7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities

doi:10.1016/j.fitote.2018.01.007

	7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities
	Zheng, Yuan-Dong1,2,3,4 ; Bai, Gang1,3,4 ; Tang, Chunping 1,2; Ke, Chang-Qiang 1,2; Yao, Sheng 1,2; Tong, Lin-Jiang 1,3; Feng, Fang 1,3; Li, Yan 1,3; Ding, Jian1,3,4 ; Xie, Hua 1,3; Ye, Yang1,2,3,4
	2018-03
发表期刊	FITOTERAPIA (IF:2.5[JCR-2023],2.7[5-Year])
ISSN	0367-326X
卷号	125 页码:174-183
发表状态	已发表
DOI	10.1016/j.fitote.2018.01.007
摘要	A phytochemical investigation of twigs of Podocarpus nagi resulted in the identification of eight new type B nagilactones (1-8), all bearing a 7 alpha,8 alpha-epoxy-9(11)-enolide substructure, along with two known analogs (9-10). Their structures were determined on the basis of spectroscopic analysis, including HRESIMS, IR and NMR experiments, and X-ray crystallographic analysis. In vitro cytotoxic assay exhibited that compounds 1, 2, 9 and 10 could induce antiproliferation against three different types of human cancer cells while compounds 3 and 5 were inactive. Notably, the IC50 value of compound 1 is 0.208 mu M for A431 human epidermoid carcinoma cells, reaching the same level as the positive control combretastatin A-4 (0.104 mu M). Furthermore, compound 1 performed a strong inhibition of cancer cells by triggering apoptosis and arresting the cell cycle at G(1) phase. These results unfold potential anticancer therapeutic applications of type B nagilactones.
关键词	Podocarpus nagi Type B nagilactone Cytotoxic activity Apoptosis
收录类别	SCI ; SCIE
语种	英语
资助项目	Chinese Academy of Sciences[GJHZ1678] ; Chinese Academy of Sciences[GJHZ1739]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000425560500027
出版者	ELSEVIER SCIENCE BV
WOS关键词	NATURAL-PRODUCTS ; NORDITERPENE DILACTONES ; ANTICANCER DRUGS ; DISCOVERY ; MICROTUBULES ; NAGILACTONES ; PODOLACTONES ; PACLITAXEL ; LACTONES ; GROWTH
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/18314
专题	生命科学与技术学院_博士生生命科学与技术学院生命科学与技术学院_特聘教授组_丁健组生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Xie, Hua; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zheng, Yuan-Dong,Bai, Gang,Tang, Chunping,et al. 7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities[J]. FITOTERAPIA,2018,125:174-183.
APA	Zheng, Yuan-Dong.,Bai, Gang.,Tang, Chunping.,Ke, Chang-Qiang.,Yao, Sheng.,...&Ye, Yang.(2018).7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities.FITOTERAPIA,125,174-183.
MLA	Zheng, Yuan-Dong,et al."7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities".FITOTERAPIA 125(2018):174-183.