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TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia | |
2018-04 | |
发表期刊 | HYPERTENSION (IF:6.9[JCR-2023],8.4[5-Year]) |
ISSN | 0194-911X |
卷号 | 71期号:4页码:671-680 |
发表状态 | 已发表 |
DOI | 10.1161/HYPERTENSIONAHA.117.10510 |
摘要 | Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women. Then, we established a mouse model with preeclampsia-like symptoms using the synthetic TLR9 agonist CpG (cytidine-phosphate-guanosine)-ODN (oligodeoxynucleotide; ODN1826). We observed the downregulation of VEGFA and the upregulation of sFLT1 in placentas from the preeclampsia-like animal model and in trophoblasts treated with CpG-ODN (ODN2006). In addition, silencing TLR9 promoted the migration and invasion of HTR8/SVneo cells. In conclusion, TLR9 is capable of robustly suppressing angiogenesis by differentially regulating the expression of VEGFA and sFLT1 at the fetomaternal interface, potentially contributing to the development of preeclampsia. |
关键词 | mice preeclampsia proteinuria toll-like receptor 9 vascular endothelial growth factor A |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | National Key Research & Development Program of China[2017YFA0504501] |
WOS研究方向 | Cardiovascular System & Cardiology |
WOS类目 | Peripheral Vascular Disease |
WOS记录号 | WOS:000426822700024 |
出版者 | LIPPINCOTT WILLIAMS & WILKINS |
WOS关键词 | CPG OLIGODEOXYNUCLEOTIDES ; EXPRESSION ; CELLS ; DNA ; OLIGONUCLEOTIDES ; GENES ; ACTIVATION ; MECHANISMS ; INHIBITORS ; PLACENTAS |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/18312 |
专题 | 生命科学与技术学院_特聘教授组_陈正军组 |
通讯作者 | Chen, Zhengjun; Cheng, Weiwei |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, 910 Hengshan Rd, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Inst Embryo Fetal Original Adult Dis, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Obstet & Gynecol, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yueyang Rd, Beijing, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | He, Biwei,Yang, Xingyu,Li, Yamei,et al. TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia[J]. HYPERTENSION,2018,71(4):671-680. |
APA | He, Biwei.,Yang, Xingyu.,Li, Yamei.,Huang, Ding.,Xu, Xin.,...&Cheng, Weiwei.(2018).TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia.HYPERTENSION,71(4),671-680. |
MLA | He, Biwei,et al."TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia".HYPERTENSION 71.4(2018):671-680. |
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