TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia
2018-04
发表期刊HYPERTENSION (IF:6.9[JCR-2023],8.4[5-Year])
ISSN0194-911X
卷号71期号:4页码:671-680
发表状态已发表
DOI10.1161/HYPERTENSIONAHA.117.10510
摘要

Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women. Then, we established a mouse model with preeclampsia-like symptoms using the synthetic TLR9 agonist CpG (cytidine-phosphate-guanosine)-ODN (oligodeoxynucleotide; ODN1826). We observed the downregulation of VEGFA and the upregulation of sFLT1 in placentas from the preeclampsia-like animal model and in trophoblasts treated with CpG-ODN (ODN2006). In addition, silencing TLR9 promoted the migration and invasion of HTR8/SVneo cells. In conclusion, TLR9 is capable of robustly suppressing angiogenesis by differentially regulating the expression of VEGFA and sFLT1 at the fetomaternal interface, potentially contributing to the development of preeclampsia.

关键词mice preeclampsia proteinuria toll-like receptor 9 vascular endothelial growth factor A
收录类别SCI ; SCIE
语种英语
资助项目National Key Research & Development Program of China[2017YFA0504501]
WOS研究方向Cardiovascular System & Cardiology
WOS类目Peripheral Vascular Disease
WOS记录号WOS:000426822700024
出版者LIPPINCOTT WILLIAMS & WILKINS
WOS关键词CPG OLIGODEOXYNUCLEOTIDES ; EXPRESSION ; CELLS ; DNA ; OLIGONUCLEOTIDES ; GENES ; ACTIVATION ; MECHANISMS ; INHIBITORS ; PLACENTAS
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/18312
专题生命科学与技术学院_特聘教授组_陈正军组
通讯作者Chen, Zhengjun; Cheng, Weiwei
作者单位
1.Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, 910 Hengshan Rd, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Inst Embryo Fetal Original Adult Dis, Shanghai, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Obstet & Gynecol, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yueyang Rd, Beijing, Peoples R China
5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
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GB/T 7714
He, Biwei,Yang, Xingyu,Li, Yamei,et al. TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia[J]. HYPERTENSION,2018,71(4):671-680.
APA He, Biwei.,Yang, Xingyu.,Li, Yamei.,Huang, Ding.,Xu, Xin.,...&Cheng, Weiwei.(2018).TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia.HYPERTENSION,71(4),671-680.
MLA He, Biwei,et al."TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia".HYPERTENSION 71.4(2018):671-680.
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