Lateral habenula in the pathophysiology of depression

doi:10.1016/j.conb.2017.10.024

	Lateral habenula in the pathophysiology of depression
	Yang, Yan 1,2; Wang, Hao 1; Hu, Ji3 ; Hu, Hailan 1,2
	2018-02
发表期刊	CURRENT OPINION IN NEUROBIOLOGY
ISSN	0959-4388
卷号	48 页码:90-96
发表状态	已发表
DOI	10.1016/j.conb.2017.10.024
摘要	Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus. Revealing the molecular, cellular and circuit properties of the LHb will help explain how abnormalities in LHb activity are linked to depressive disorders, and shed light on developing novel strategies for depression treatment.
收录类别	SCI ; SCIE
语种	英语
资助项目	Fundamental Research Funds for the Central Universities[2017QNA7015]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000427101600013
出版者	CURRENT BIOLOGY LTD
WOS关键词	VENTRAL TEGMENTAL AREA ; DORSAL RAPHE NUCLEUS ; NEGATIVE MOTIVATIONAL VALUE ; MIDBRAIN DOPAMINE NEURONS ; EFFERENT CONNECTIONS ; BASAL GANGLIA ; SYNAPTIC POTENTIATION ; PREFRONTAL CORTEX ; MAJOR DEPRESSION ; SUBSTANTIA-NIGRA
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/18295
专题	生命科学与技术学院_PI研究组_胡霁组
通讯作者	Hu, Ji; Hu, Hailan
作者单位	1.Zhejiang Univ, Qiushi Acad Adv Studies, Interdisciplinary Inst Neurosci & Technol,Sch Med, Ctr Neurosci,Key Lab Med Neurobiol,Minist Hlth Ch, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Sch Med, Mental Hlth Ctr, Hangzhou 310013, Zhejiang, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Yan,Wang, Hao,Hu, Ji,et al. Lateral habenula in the pathophysiology of depression[J]. CURRENT OPINION IN NEUROBIOLOGY,2018,48:90-96.
APA	Yang, Yan,Wang, Hao,Hu, Ji,&Hu, Hailan.(2018).Lateral habenula in the pathophysiology of depression.CURRENT OPINION IN NEUROBIOLOGY,48,90-96.
MLA	Yang, Yan,et al."Lateral habenula in the pathophysiology of depression".CURRENT OPINION IN NEUROBIOLOGY 48(2018):90-96.