Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

doi:10.1016/j.phytochem.2016.03.006

	Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity
	Yao, Sheng 1,2,3; To, Kenneth Kin-Wah 2,3,4; Ma, Liang 1,2,3; Yin, Chun 2,3,5; Tang, Chunping 1,2,3; Chai, Stella 2,3,5; Ke, Chang-Qiang 1,2,3; Lin, Ge 2,3,5; Ye, Yang1,2,3,6
	2016-06
发表期刊	PHYTOCHEMISTRY (IF:3.2[JCR-2023],3.4[5-Year])
ISSN	0031-9422
卷号	126 页码:47-58
发表状态	已发表
DOI	10.1016/j.phytochem.2016.03.006
摘要	A polyoxypregnane aglycone,12 beta-O-acetyl-11 alpha-O-isobutyryltenacigenin B, and four polyoxypregnane glycosides with a pachybionic acid ester moiety, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-isobutylyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandrony1)-11 alpha-O-tigloyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-2-methylbutylyltenacigenin B, and 12 beta-O-acetyl-3-O-glucopyranosyl-(1 -> 4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-D-oleandronyl)-11 alpha-O-tigloyltenacigenin B, were isolated from the canes of Marsdenia tenacissima, together with a disaccharide derivative. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations were further determined by X-ray crystallographic analysis. With the exception of the disaccharide derivative, all five compounds are unusual naturally occurring polyoxypregnane glycosides bearing an open-chain sugar moiety. Two of these exhibit a wide spectrum of chemoresistance reversal activity, and potential mechanisms were studied accordingly. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Marsdenia tenacissima Asclepiadaceae C-21 steroids Open-chain sugars Absolute configuration X-ray crystallography diffraction Chemoresistance reversal activity Structure elucidation
收录类别	SCI ; IC
语种	英语
资助项目	Chinese University of Hong Kong[2008.1.079]
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号	WOS:000375166600006
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	MULTIDRUG-RESISTANCE ; PREGNANE GLYCOSIDES ; DIE GLYKOSIDE ; OLIGOSACCHARIDES ; STEMS ; OVEREXPRESSION ; CYTOTOXICITY ; CONSTITUENTS ; TRANSPORTER ; SENSITIVITY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1827
专题	生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Lin, Ge; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Chem, State Key Lab Drug Res & Nat Prod, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Beijing 100864, Peoples R China 3.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 4.Chinese Univ Hong Kong, Fac Med, Sch Pharm, Hong Kong, Hong Kong, Peoples R China 5.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yao, Sheng,To, Kenneth Kin-Wah,Ma, Liang,et al. Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity[J]. PHYTOCHEMISTRY,2016,126:47-58.
APA	Yao, Sheng.,To, Kenneth Kin-Wah.,Ma, Liang.,Yin, Chun.,Tang, Chunping.,...&Ye, Yang.(2016).Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.PHYTOCHEMISTRY,126,47-58.
MLA	Yao, Sheng,et al."Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity".PHYTOCHEMISTRY 126(2016):47-58.