Somatic human ZBTB7A zinc finger mutations promote cancer progression

doi:10.1038/onc.2015.371

	Somatic human ZBTB7A zinc finger mutations promote cancer progression
	Liu, X-S1,2 ; Liu, Z.3; Gerarduzzi, C.1; Choi, D. E.1; Ganapathy, S.1; Pandolfi, P. P.4,5; Yuan, Z-M 1
	2016-06-09
发表期刊	ONCOGENE (IF:6.9[JCR-2023],7.5[5-Year])
ISSN	0950-9232
卷号	35 期号:23 页码:3071-3078
发表状态	已发表
DOI	10.1038/onc.2015.371
摘要	We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic genes and its downregulation in human cancer contributes to tumor metabolism. As reduced expression of ZBTB7A is found only in a subset of human cancers, we explored alternative mechanisms of its inactivation by mining human cancer genome databases. We discovered recurrent somatic mutations of ZBTB7A in multiple types of human cancers with a marked enrichment of mutations within the zinc finger domain. Functional characterization of the mutants demonstrated that mutations within the zinc finger region of ZBTB7A invariably resulted in loss of function. As a consequence, the glycolytic genes were markedly upregulated in cancer cells harboring ZBTB7A zinc finger mutation, leading to increased glycolysis and proliferation. Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
收录类别	SCI
语种	英语
资助项目	NIH/NCI[R01CA085679] ; NIH/NCI[RO1CA167814] ; NIH/NCI[RO1CA125144]
WOS研究方向	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS记录号	WOS:000377474500012
出版者	NATURE PUBLISHING GROUP
WOS关键词	TRANSCRIPTIONAL REPRESSOR ; POZ DOMAIN ; GENE ; PROTEINS ; LRF
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1808
专题	生命科学与技术学院生命科学与技术学院_PI研究组_刘雪松组
通讯作者	Yuan, Z-M
作者单位	1.Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, 665 Huntington Ave, Boston, MA 02115 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 3.Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA 4.Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med,Dept Med, Canc Genet Program,Beth Israel Deaconess Canc Ctr, Boston, MA 02215 USA 5.Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med,Dept Pathol, Canc Genet Program,Beth Israel Deaconess Canc Ctr, Boston, MA 02215 USA
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, X-S,Liu, Z.,Gerarduzzi, C.,et al. Somatic human ZBTB7A zinc finger mutations promote cancer progression[J]. ONCOGENE,2016,35(23):3071-3078.
APA	Liu, X-S.,Liu, Z..,Gerarduzzi, C..,Choi, D. E..,Ganapathy, S..,...&Yuan, Z-M.(2016).Somatic human ZBTB7A zinc finger mutations promote cancer progression.ONCOGENE,35(23),3071-3078.
MLA	Liu, X-S,et al."Somatic human ZBTB7A zinc finger mutations promote cancer progression".ONCOGENE 35.23(2016):3071-3078.