Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

doi:10.1038/s41467-022-30119-8

	Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis
	Zhang, Yun 1; Li, Shuaijun 2; Jin, Peisheng 3; Shang, Ting 4; Sun, Ruizhu 2; Lu, Laiya 1; Guo, Kaijin 5; Liu, Jiping 1; Tong, Yongjuan 4; Wang, Junbang 6; Liu, Sanhong7 ; Wang, Chen7 ; Kang, Yubin 4; Zhu, Wenmin 1; Wang, Qian 2; Zhang, Xiaoren 8; Yin, Feng 1; Sun, Yi Eve 1; Cui, Lei 1,2,4
	2022-05-04
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-30119-8
摘要	["Damaged hyaline cartilage has no capacity for self-healing, making osteoarthritis (OA) \"difficult-to-treat\". Cartilage destruction is central to OA patho-etiology and is mediated by matrix degrading enzymes. Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributes to OA progression. Supplementation of exogenous miR-17 or its endogenous induction by growth differentiation factor 5, effectively prevented OA by simultaneously targeting pathological catabolic factors including matrix metallopeptidase-3/13 (MMP3/13), aggrecanase-2 (ADAMTS5), and nitric oxide synthase-2 (NOS2). Single-cell RNA sequencing of hyaline cartilage revealed two distinct superficial chondrocyte populations (C1/C2). C1 expressed physiological catabolic factors including MMP2, and C2 carries synovial features, together with C3 in the middle zone. MiR-17 is highly expressed in both superficial and middle chondrocytes under physiological conditions, and maintains the physiological catabolic and anabolic balance potentially by restricting HIF-1 alpha signaling. Together, this study identified dual functions of miR-17 in maintaining cartilage homeostasis and prevention of OA.","Osteoarthritic (OA) is characterized by progressive destruction of joint cartilage. Here, the authors show that microRNA-17 plays a dual role in maintaining cartilage homeostasis and in the prevention of osteoarthritis, by targeting hypoxia-inducible factor-1 alpha as well as multiple matrix-degrading enzymes."]
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Ministry of Science and Technology of China[2020YFC2002800] ; Beijing Natural Science Foundation[2019-A08] ; Natural Science Foundation of China[81401845,81471798,82030035,31620103904]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000790940000008
出版者	NATURE PORTFOLIO
Scopus 记录号	2-s2.0-85129363841
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/180896
专题	免疫化学研究所_特聘教授组_干细胞生物学实验室
通讯作者	Sun, Yi Eve; Cui, Lei
作者单位	1.Shanghai Institute of Stem Cell Research and Clinical Translation & Institute for Regenerative Medicine & Department of Joint Surgery,Shanghai East Hospital,Tongji University School of Medicine,Shanghai,China 2.Key Laboratory of spine and spinal cord injury repair and regeneration,Ministry of Education of the People’s Republic of China & Department of Orthopedics,Tongji Hospital,Tongji University School of Medicine,Shanghai,China 3.Department of Plastic Surgery,Affiliated Hospital of Xuzhou Medical University,Xuzhou,China 4.Department of Plastic Surgery,Beijing Shijitan Hospital,Capital Medical University,Beijing,China 5.Department of Orthopedics,Affiliated Hospital of Xuzhou Medical University,Xuzhou,China 6.Translational Stem Cell Research Center,Tongji Hospital,Tongji University School of Medicine,Shanghai,China 7.Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai,China 8.Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation,State Key Laboratory of Respiratory Disease,Affiliated Cancer Hospital & Institute of Guangzhou Medical University,Guangzhou,China
推荐引用方式 GB/T 7714	Zhang, Yun,Li, Shuaijun,Jin, Peisheng,et al. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Zhang, Yun.,Li, Shuaijun.,Jin, Peisheng.,Shang, Ting.,Sun, Ruizhu.,...&Cui, Lei.(2022).Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.NATURE COMMUNICATIONS,13(1).
MLA	Zhang, Yun,et al."Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis".NATURE COMMUNICATIONS 13.1(2022).