Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma

doi:10.18632/oncotarget.9104

	Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma
	Chen, Peizhan 1; Li, Bin 1,2,3; Zhu, Yan 4; Chen, Wei 5; Liu, Xin 5; Li, Mian 1; Duan, Xiaohua 1; Yi, Bin 2,3; Wang, Jinghan 6; Liu, Chen 2,3; Luo, Xiangji 2,3; Li, Xiaoguang 1; Li, Jingquan 1; Liang, Lijian 5; Yin, Xiaoyu 5; Wang, Hui1,7,8 ; Jiang, Xiaoqing 2,3
	2016-06-14
发表期刊	ONCOTARGET (IF:5.168[JCR-2016],5.312[5-Year])
ISSN	1949-2553
卷号	7 期号:24 页码:37319-37330
发表状态	已发表
DOI	10.18632/oncotarget.9104
摘要	As the conventional staging systems have poor prognosis prediction ability for patients with perihilar cholangiocarcinoma (pCCA), we established and validated an effective prognostic nomogram for pCCA patients based on their personal and tumor characteristics. A total of 235 patients who received curative intent resections at the Eastern Hepatobiliary Surgery Hospital from 2000 to 2009 were recruited as the primary training cohort. Age, preoperative CA19-9 levels, portal vein involvement, hepatic artery invasion, lymph node metastases, and surgical treatment outcomes (R0 or R1/2) were independent prognostic factors for pCCA patients in the primary cohort as suggested by the multivariate analyses and these were included in the established nomogram. The calibration curve showed good agreement between overall survival probability of pCCA patients for the nomogram predictions and the actual observations and the concordance index (C-index) was 0.68 (95% CI, 0.61-0.71). The C-index values and time-dependent ROC tests suggested that the nomogram is superior to the conventional staging systems including the Bismuth-Corlette, Gazzaniga, Memorial Sloan Kettering Cancer Center (MSKCC), American Joint Committee on Cancer (AJCC) TNM 7th edition, and Mayo Clinic. The nomogram also performed better than the traditional staging system in the internal cohort with 93 pCCA patients from the same institution and an external validation cohort including 84 pCCA patients from another institution in predicting the overall survival of the pCCA patients as suggested by the C-index values and the time-dependent ROC tests. In summary, the proposed nomogram has superior predictive accuracy of prognosis for resectable pCCA patients.
关键词	perihilar cholangiocarcinoma overall survival nomogram
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[14391901800] ; Science and Technology Commission of Shanghai Municipality[14140902100] ; Science and Technology Commission of Shanghai Municipality[13XD1400200] ; Science and Technology Commission of Shanghai Municipality[13140902902]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000377756800141
出版者	IMPACT JOURNALS LLC
WOS关键词	AMERICAN JOINT COMMITTEE ; HILAR CHOLANGIOCARCINOMA ; INTRAHEPATIC CHOLANGIOCARCINOMA ; SURGICAL-TREATMENT ; STAGING SYSTEM ; SERUM CA19-9 ; CANCER ; DIAGNOSIS ; THERAPY ; SURVIVAL
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1805
专题	生命科学与技术学院_特聘教授组_王慧组
通讯作者	Yin, Xiaoyu; Wang, Hui; Jiang, Xiaoqing
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Secondary Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Biliary Tract Surg Dept 1, Shanghai 200433, Peoples R China 3.Secondary Mil Med Univ, Diag & Treatment Ctr Malignant Biliary Tract Dis, Shanghai 200433, Peoples R China 4.Secondary Mil Med Univ, Dept Pathol, Changhai Hosp, Shanghai 200433, Peoples R China 5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pancreatobiliary Surg, Guangzhou 510080, Guangdong, Peoples R China 6.Navy Gen Hosp, Dept Hepatobiliary Surg, Beijing 100048, Peoples R China 7.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Peizhan,Li, Bin,Zhu, Yan,et al. Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma[J]. ONCOTARGET,2016,7(24):37319-37330.
APA	Chen, Peizhan.,Li, Bin.,Zhu, Yan.,Chen, Wei.,Liu, Xin.,...&Jiang, Xiaoqing.(2016).Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma.ONCOTARGET,7(24),37319-37330.
MLA	Chen, Peizhan,et al."Establishment and validation of a prognostic nomogram for patients with resectable perihilar cholangiocarcinoma".ONCOTARGET 7.24(2016):37319-37330.