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The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice | |
2016-08-09 | |
Source Publication | ELIFE
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ISSN | 2050-084X |
Volume | 5 |
Status | 已发表 |
DOI | 10.7554/eLife.18197 |
Abstract | Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding. |
Indexed By | SCI |
Funding Project | Chinese Academy of Sciences[XDB02040003] |
WOS Research Area | Life Sciences & Biomedicine - Other Topics |
WOS Subject | Biology |
WOS ID | WOS:000384421000001 |
Publisher | ELIFE SCIENCES PUBLICATIONS LTD |
WOS Keyword | OUTER SUBVENTRICULAR ZONE ; MAMMALIAN CEREBRAL-CORTEX ; RADIAL GLIA ; HUMAN BRAIN ; ADHERENS JUNCTIONS ; SIGNALING PATHWAY ; MOUSE NEOCORTEX ; GERMINAL ZONE ; HUMAN LINEAGE ; SELF-RENEWAL |
Original Document Type | Article |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1757 |
Collection | 生命科学与技术学院_特聘教授组_罗振革组 生命科学与技术学院_PI研究组_罗振革组 |
Co-First Author | Hou, Qiong-Qiong |
Corresponding Author | Luo, Zhen-Ge |
Affiliation | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 2.Chinese Acad Sci, State Key Lab Neurosci, Shanghai, Peoples R China 3.Chinese Acad Sci Univ, Beijing, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China 5.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China 6.Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China 7.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China 8.Chinese Acad Sci, Inst Biophys, Beijing, Peoples R China 9.ShanghaiTech Univ, Shanghai, Peoples R China |
Corresponding Author Affilication | ShanghaiTech University |
Recommended Citation GB/T 7714 | Ju, Xiang-Chun,Hou, Qiong-Qiong,Sheng, Ai-Li,et al. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice[J]. ELIFE,2016,5. |
APA | Ju, Xiang-Chun.,Hou, Qiong-Qiong.,Sheng, Ai-Li.,Wu, Kong-Yan.,Zhou, Yang.,...&Luo, Zhen-Ge.(2016).The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.ELIFE,5. |
MLA | Ju, Xiang-Chun,et al."The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice".ELIFE 5(2016). |
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