The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
2016-08-09
Source PublicationELIFE
ISSN2050-084X
Volume5
Status已发表
DOI10.7554/eLife.18197
Abstract

Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding.

Indexed BySCI
Funding ProjectChinese Academy of Sciences[XDB02040003]
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000384421000001
PublisherELIFE SCIENCES PUBLICATIONS LTD
WOS KeywordOUTER SUBVENTRICULAR ZONE ; MAMMALIAN CEREBRAL-CORTEX ; RADIAL GLIA ; HUMAN BRAIN ; ADHERENS JUNCTIONS ; SIGNALING PATHWAY ; MOUSE NEOCORTEX ; GERMINAL ZONE ; HUMAN LINEAGE ; SELF-RENEWAL
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1757
Collection生命科学与技术学院_特聘教授组_罗振革组
生命科学与技术学院_PI研究组_罗振革组
Co-First AuthorHou, Qiong-Qiong
Corresponding AuthorLuo, Zhen-Ge
Affiliation
1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China
2.Chinese Acad Sci, State Key Lab Neurosci, Shanghai, Peoples R China
3.Chinese Acad Sci Univ, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China
5.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China
6.Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China
7.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China
8.Chinese Acad Sci, Inst Biophys, Beijing, Peoples R China
9.ShanghaiTech Univ, Shanghai, Peoples R China
Corresponding Author AffilicationShanghaiTech University
Recommended Citation
GB/T 7714
Ju, Xiang-Chun,Hou, Qiong-Qiong,Sheng, Ai-Li,et al. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice[J]. ELIFE,2016,5.
APA Ju, Xiang-Chun.,Hou, Qiong-Qiong.,Sheng, Ai-Li.,Wu, Kong-Yan.,Zhou, Yang.,...&Luo, Zhen-Ge.(2016).The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.ELIFE,5.
MLA Ju, Xiang-Chun,et al."The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice".ELIFE 5(2016).
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