Sperm tsRNAs and acquired metabolic disorders

doi:10.1530/JOE-16-0185

	Sperm tsRNAs and acquired metabolic disorders
	Yan, Menghong 1; Zhai, Qiwei1,2
	2016-09
发表期刊	JOURNAL OF ENDOCRINOLOGY
ISSN	0022-0795
卷号	230 期号:3 页码:F13-F18
发表状态	已发表
DOI	10.1530/JOE-16-0185
摘要	Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as DNA methylation, histone modification and small non-coding RNAs. Recent evidence shows that sperm tRNA-derived small RNAs (tsRNAs) as a type of paternal epigenetic information carrier may mediate intergenerational inheritance. In this review, we provide current knowledge of a father's influence on metabolic disorders in subsequent generations and discuss the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission.
关键词	tsRNA acquired metabolic disorder intergenerational inheritance RNA modification
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12030204]
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000384195700001
出版者	BIOSCIENTIFICA LTD
WOS关键词	TRANSGENERATIONAL EPIGENETIC INHERITANCE ; DIET-INDUCED OBESITY ; MAMMALS ; RNAS ; METHYLATION ; RESISTANCE ; DNMT2
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1740
专题	生命科学与技术学院_特聘教授组_翟琦巍组
通讯作者	Zhai, Qiwei
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yan, Menghong,Zhai, Qiwei. Sperm tsRNAs and acquired metabolic disorders[J]. JOURNAL OF ENDOCRINOLOGY,2016,230(3):F13-F18.
APA	Yan, Menghong,&Zhai, Qiwei.(2016).Sperm tsRNAs and acquired metabolic disorders.JOURNAL OF ENDOCRINOLOGY,230(3),F13-F18.
MLA	Yan, Menghong,et al."Sperm tsRNAs and acquired metabolic disorders".JOURNAL OF ENDOCRINOLOGY 230.3(2016):F13-F18.