Skin immunity: dissecting the complex biology of our body's outer barrier

doi:10.1038/s41385-022-00505-y

	Skin immunity: dissecting the complex biology of our body's outer barrier
	Zhang, Chenlu1,2 ; Merana, Geil R.3,4; Harris-Tryon, Tamia 1; Scharschmidt, Tiffany C.3
	2022-04
发表期刊	MUCOSAL IMMUNOLOGY (IF:7.9[JCR-2023],7.9[5-Year])
ISSN	1933-0219
EISSN	1935-3456
发表状态	已发表
DOI	10.1038/s41385-022-00505-y
摘要	Our skin contributes critically to health via its role as a barrier tissue, carefully regulating passage of key substrates while also providing defense against exogenous threats. Immunological processes are integral to almost every skin function and paramount to our ability to live symbiotically with skin commensal microbes and other environmental stimuli. While many parallels can be drawn to immunobiology at other mucosal sites, skin immunity demonstrates unique features that relate to its distinct topography, chemical composition and microbial ecology. Here we provide an overview of skin as an immune organ, with reference to the broader context of mucosal immunology. We review paradigms of innate as well as adaptive immune function and highlight how skin-specific structures such as hair follicles and sebaceous glands interact and contribute to these processes. Finally, we highlight for the mucosal immunology community a few emerging areas of interest for the skin immunity field moving forward.
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收录类别	SCI ; SCIE
语种	英语
资助项目	NIAMS[K08 AR076459] ; NIAID[DP2AI44968]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000777221400001
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/171478
专题	生命科学与技术学院_PI研究组_张晨璐组
通讯作者	Harris-Tryon, Tamia; Scharschmidt, Tiffany C.
作者单位	1.Univ Texas Southwestern, Dept Dermatol, Dallas, TX 75390 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA 4.23andMe, Sunnyvale, CA USA
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,et al. Skin immunity: dissecting the complex biology of our body's outer barrier[J]. MUCOSAL IMMUNOLOGY,2022.
APA	Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,&Scharschmidt, Tiffany C..(2022).Skin immunity: dissecting the complex biology of our body's outer barrier.MUCOSAL IMMUNOLOGY.
MLA	Zhang, Chenlu,et al."Skin immunity: dissecting the complex biology of our body's outer barrier".MUCOSAL IMMUNOLOGY (2022).