Skin immunity: dissecting the complex biology of our body's outer barrier
2022-04
发表期刊MUCOSAL IMMUNOLOGY (IF:7.9[JCR-2023],7.9[5-Year])
ISSN1933-0219
EISSN1935-3456
发表状态已发表
DOI10.1038/s41385-022-00505-y
摘要Our skin contributes critically to health via its role as a barrier tissue, carefully regulating passage of key substrates while also providing defense against exogenous threats. Immunological processes are integral to almost every skin function and paramount to our ability to live symbiotically with skin commensal microbes and other environmental stimuli. While many parallels can be drawn to immunobiology at other mucosal sites, skin immunity demonstrates unique features that relate to its distinct topography, chemical composition and microbial ecology. Here we provide an overview of skin as an immune organ, with reference to the broader context of mucosal immunology. We review paradigms of innate as well as adaptive immune function and highlight how skin-specific structures such as hair follicles and sebaceous glands interact and contribute to these processes. Finally, we highlight for the mucosal immunology community a few emerging areas of interest for the skin immunity field moving forward.
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收录类别SCI ; SCIE
语种英语
资助项目NIAMS[K08 AR076459] ; NIAID[DP2AI44968]
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000777221400001
出版者SPRINGERNATURE
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/171478
专题生命科学与技术学院_PI研究组_张晨璐组
通讯作者Harris-Tryon, Tamia; Scharschmidt, Tiffany C.
作者单位
1.Univ Texas Southwestern, Dept Dermatol, Dallas, TX 75390 USA
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
4.23andMe, Sunnyvale, CA USA
第一作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,et al. Skin immunity: dissecting the complex biology of our body's outer barrier[J]. MUCOSAL IMMUNOLOGY,2022.
APA Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,&Scharschmidt, Tiffany C..(2022).Skin immunity: dissecting the complex biology of our body's outer barrier.MUCOSAL IMMUNOLOGY.
MLA Zhang, Chenlu,et al."Skin immunity: dissecting the complex biology of our body's outer barrier".MUCOSAL IMMUNOLOGY (2022).
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