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Skin immunity: dissecting the complex biology of our body's outer barrier | |
2022-04 | |
发表期刊 | MUCOSAL IMMUNOLOGY (IF:7.9[JCR-2023],7.9[5-Year]) |
ISSN | 1933-0219 |
EISSN | 1935-3456 |
发表状态 | 已发表 |
DOI | 10.1038/s41385-022-00505-y |
摘要 | Our skin contributes critically to health via its role as a barrier tissue, carefully regulating passage of key substrates while also providing defense against exogenous threats. Immunological processes are integral to almost every skin function and paramount to our ability to live symbiotically with skin commensal microbes and other environmental stimuli. While many parallels can be drawn to immunobiology at other mucosal sites, skin immunity demonstrates unique features that relate to its distinct topography, chemical composition and microbial ecology. Here we provide an overview of skin as an immune organ, with reference to the broader context of mucosal immunology. We review paradigms of innate as well as adaptive immune function and highlight how skin-specific structures such as hair follicles and sebaceous glands interact and contribute to these processes. Finally, we highlight for the mucosal immunology community a few emerging areas of interest for the skin immunity field moving forward. |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | NIAMS[K08 AR076459] ; NIAID[DP2AI44968] |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000777221400001 |
出版者 | SPRINGERNATURE |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/171478 |
专题 | 生命科学与技术学院_PI研究组_张晨璐组 |
通讯作者 | Harris-Tryon, Tamia; Scharschmidt, Tiffany C. |
作者单位 | 1.Univ Texas Southwestern, Dept Dermatol, Dallas, TX 75390 USA 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA 4.23andMe, Sunnyvale, CA USA |
第一作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,et al. Skin immunity: dissecting the complex biology of our body's outer barrier[J]. MUCOSAL IMMUNOLOGY,2022. |
APA | Zhang, Chenlu,Merana, Geil R.,Harris-Tryon, Tamia,&Scharschmidt, Tiffany C..(2022).Skin immunity: dissecting the complex biology of our body's outer barrier.MUCOSAL IMMUNOLOGY. |
MLA | Zhang, Chenlu,et al."Skin immunity: dissecting the complex biology of our body's outer barrier".MUCOSAL IMMUNOLOGY (2022). |
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