Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease

doi:10.1016/j.biomaterials.2016.06.056

	Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease
	Cui, Zhaowen1,2 ; Bu, Wenbo 1,3; Fan, Wenpei 1; Zhang, Jiawen 4; Ni, Dalong 1; Liu, Yanyan 1; Wang, Jing 4; Liu, Jianan 1; Yao, Zhenwei 4; Shi, Jianlin1,2
	2016-10
发表期刊	BIOMATERIALS (IF:12.8[JCR-2023],13.1[5-Year])
ISSN	0142-9612
卷号	104 页码:158-167
发表状态	已发表
DOI	10.1016/j.biomaterials.2016.06.056
摘要	As a distinct feature of Alzheimer's disease (AD), the presence of excess metal ions in the brain is most probably one of the main causative factors for the aggregation of beta-Amyloid (A beta) proteins. The design of nanoprobes for detection and control of ion concentrations will be of great importance in predicting the progression of AD and simultaneously providing effective treatments. Herein, we report the design and synthesis of a novel yet smart nanoprobe that can sensitively detect the Cu2+ concentration and concurrently capture Cu2+ both in vitro and in vivo. The designed nanoprobe (UCHQ) combines two main components: upconversion nanoparticles (UCNPs) used for the detection and upconversion luminescence (UCL) imaging of Cu2+ upon 980 nm exposure and the chelator 8-hydroxyquinoline-2-carboxylic acid (HQC) used for chelating Cu2+ and AD therapy. The results show that the emission intensity of UCHQ is highly dependent on the Cu2+ concentrations due to the luminescence resonance energy transfer (LRET) from UCNPs to HQC-bonded Cu2+. Fascinatingly, the as-constructed UCHQs could be used for UCL imaging of A beta both in cells and AD mice. Most importantly, UCHQs could not only inhibit the A beta aggregation-induced apoptosis via capturing overmuch Cu2+ but also accelerate the nontoxic structural transformation of A beta. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Upconversion nanoparticles Alzheimer's disease Nanotheranostics Sensing LRET
收录类别	SCI ; EI
语种	英语
资助项目	Youth Innovation Promotion Association CAS[2015201]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000382345000014
出版者	ELSEVIER SCI LTD
EI入藏号	20163002640137
EI主题词	Cell death ; Chelation ; Energy transfer ; Luminescence ; Metal ions ; Metals ; Nanoparticles ; Nanoprobes ; Proteins
EI分类号	Medicine and Pharmacology:461.6 ; Biology:461.9 ; Metallurgy:531.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Solid State Physics:933
WOS关键词	IN-VIVO DETECTION ; AMYLOID-BETA ; A-BETA ; TRANSGENIC MICE ; NANOPARTICLES ; BRAIN ; IONS ; AGGREGATION ; HYPOTHESIS ; COGNITION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1698
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_施剑林组物质科学与技术学院_博士生
通讯作者	Bu, Wenbo; Shi, Jianlin
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Shanghai Tech Univ, Shanghai 201210, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 4.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China
第一作者单位	上海科技大学
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Cui, Zhaowen,Bu, Wenbo,Fan, Wenpei,et al. Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease[J]. BIOMATERIALS,2016,104:158-167.
APA	Cui, Zhaowen.,Bu, Wenbo.,Fan, Wenpei.,Zhang, Jiawen.,Ni, Dalong.,...&Shi, Jianlin.(2016).Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease.BIOMATERIALS,104,158-167.
MLA	Cui, Zhaowen,et al."Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease".BIOMATERIALS 104(2016):158-167.