Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma

doi:10.1038/cr.2016.111

	Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma
	Li, Fei 1,2,3,4; Fang, Zhaoyuan 8; Zhang, Jian 1,2,3,4; Li, Chen 1,2,3; Liu, Hongyan 1,2,3; Xia, Jufeng 1,2,3; Zhu, Hongwen 1,2,3,4; Guo, Chenchen 1,2,3,4; Qin, Zhen 1,2,3,4; Li, Fuming 1,2,3; Han, Xiangkun 1,2,3; Wang, Yuetong 1,2,3,4; Feng, Yan 1,2,3; Wang, Ye 1,2,3; Zhang, Wenjing 1,2,3,4; Wang, Zuoyun 1,2,3; Jin, Yujuan 1,2,3; Sun, Yihua 6,7; Wei, Wenyi 9; Zeng, Rong1,2,5 ; Chen, Haiquan 6,7; Ji, Hongbin1,2,3,5
	2016-10
发表期刊	CELL RESEARCH
ISSN	1001-0602
卷号	26 期号:10 页码:1149-1164
发表状态	已发表
DOI	10.1038/cr.2016.111
摘要	Lung squamous cell carcinoma (SCC) is one of the major subtypes of lung cancer. Our current knowledge of oncogenic drivers in this specific subtype of lung cancer is largely limited compared with lung adenocarcinoma (ADC). Through exon array analyses, molecular analyses and functional studies, we here identify the TRA2B-DNAH5 fusion as a novel oncogenic driver in lung SCC. We found that this gene fusion occurs exclusively in lung SCC (3.1%, 5/163), but not in lung ADC (0/119). Through mechanistic studies, we further revealed that this TRA2B-DNAH5 fusion promotes lung SCC malignant progression through regulating a SIRT6-ERK1/2-MMP1 signaling axis. We show that inhibition of ERK1/2 activation using selumetinib efficiently inhibits the growth of lung SCC with TRA2B-DNAH5 fusion expression. These findings improve our current knowledge of oncogenic drivers in lung SCC and provide a potential therapeutic strategy for lung SCC patients with TRA2B-DNAH5 fusion.
关键词	lung squamous cell carcinoma molecular targeted therapy exon array analyses TRA2B-DNAH5 fusion selumetinib
收录类别	SCI
语种	英语
资助项目	Shanghai Institutes for Biological Sciences[2013KIP303] ; Shanghai Institutes for Biological Sciences[2013KIP102] ; Shanghai Institutes for Biological Sciences[2014KIP304]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000386135200009
出版者	INST BIOCHEMISTRY & CELL BIOLOGY
WOS关键词	ACTIVATED PROTEIN-KINASE ; RET GENE FUSION ; NEVER-SMOKERS ; MATRIX METALLOPROTEINASE-1 ; SIGNALING PATHWAY ; CANCER ; MUTATIONS ; EXPRESSION ; ADENOCARCINOMA ; SIRT6
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1688
专题	生命科学与技术学院_特聘教授组_曾嵘组生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Ji, Hongbin
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China 6.Fudan Univ, Shanghai Canc Ctr, Dept Thorac Surg, Shanghai 200032, Peoples R China 7.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China 9.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Fei,Fang, Zhaoyuan,Zhang, Jian,et al. Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma[J]. CELL RESEARCH,2016,26(10):1149-1164.
APA	Li, Fei.,Fang, Zhaoyuan.,Zhang, Jian.,Li, Chen.,Liu, Hongyan.,...&Ji, Hongbin.(2016).Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma.CELL RESEARCH,26(10),1149-1164.
MLA	Li, Fei,et al."Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma".CELL RESEARCH 26.10(2016):1149-1164.