RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis

doi:10.1038/cddis.2016.309

	RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
	Ge, Qiu-Lin 1; Liu, San-Hong2,3,6 ; Ai, Zhi-Hong 1; Tao, Min-Fang 1; Ma, Li 1; Wen, Shan-Yun 4; Dai, Miao 1; Liu, Fei 1; Liu, Han-Shao 2,3; Jiang, Rong-Zhen 1; Xue, Zhuo-Wei 1; Jiang, Yu-Hang 2,3; Sun, Xiao-Hua 2,3; Hu, Yi-Ming 2,3; Zhao, Yong-Xu 2,3; Chen, Xi 2,3; Tao, Yu 2,3; Zhu, Xiao-Lu 1; Ding, Wen-Jing 5; Yang, Bing-Qing 1; Liu, Dan-Dan 2,3; Zhang, Xiao-Ren 2,3; Teng, Yin-Cheng 1
	2016-10
发表期刊	CELL DEATH & DISEASE
ISSN	2041-4889
卷号	7
发表状态	已发表
DOI	10.1038/cddis.2016.309
摘要	Dysfunction of nuclear factor-kappa B (NF-kappa B) signaling has been causally associated with numerous human malignancies. Although the NF-kappa B family of genes has been implicated in endometrial carcinogenesis, information regarding the involvement of central regulators of NF-kappa B signaling in human endometrial cancer (EC) is limited. Here, we investigated the specific roles of canonical and noncanonical NF-kappa B signaling in endometrial tumorigenesis. We found that NF-kappa B RelB protein, but not RelA, displayed high expression in EC samples and cell lines, with predominant elevation in endometrioid adenocarcinoma (EEC). Moreover, tumor cell-intrinsic RelB was responsible for the abundant levels of c-Myc, cyclin D1, Bcl-2 and Bcl-xL, which are key regulators of cell cycle transition, apoptosis and proliferation in EEC. In contrast, p27 expression was enhanced by RelB depletion. Thus, increased RelB in human EC is associated with enhanced EEC cell growth, leading to endometrial cell tumorigenicity. Our results reveal that regulatory RelB in noncanonical NF-kappa B signaling may serve as a therapeutic target to block EC initiation.
收录类别	SCI
语种	英语
资助项目	Shanghai Municipal Science and Technology Commission Foundation[13JC1404502]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000387358800019
出版者	NATURE PUBLISHING GROUP
WOS关键词	ESTROGEN-RECEPTOR ; CANCER-CELLS ; CROSS-TALK ; ACTIVATION ; EXPRESSION ; TARGET
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1687
专题	免疫化学研究所_特聘教授组_干细胞生物学实验室
通讯作者	Zhang, Xiao-Ren; Teng, Yin-Cheng
作者单位	1.Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Obstet & Gynecol, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China 4.Shanghai Songjiang Dist Cent Hosp, Dept Obstet & Gynecol, Shanghai, Peoples R China 5.Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China 6.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Ge, Qiu-Lin,Liu, San-Hong,Ai, Zhi-Hong,et al. RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis[J]. CELL DEATH & DISEASE,2016,7.
APA	Ge, Qiu-Lin.,Liu, San-Hong.,Ai, Zhi-Hong.,Tao, Min-Fang.,Ma, Li.,...&Teng, Yin-Cheng.(2016).RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis.CELL DEATH & DISEASE,7.
MLA	Ge, Qiu-Lin,et al."RelB/NF-kappa B links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis".CELL DEATH & DISEASE 7(2016).