Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens

doi:10.3390/nano12050779

KMS > 物质科学与技术学院 > PI研究组 > Osamu Terasaki组

	Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens
	Nieto-Arguello, Alfonso 1; Medina-Cruz, David 2; Perez-Ramirez, Yeremi S.1; Perez-Garcia, Sergio A.3; Velasco-Soto, Miguel A.1; Jafari, Zeinab 1; De Leon, Israel 1; Gonzalez, Maria Ujue 4; Huttel, Yves 5; Martinez, Lidia 5; Mayoral, Alvaro6,7,8 ; Webster, Thomas J.2; Garcia-Martin, Jose M.4; Cholula-Diaz, Jorge L.1
	2022-03
发表期刊	NANOMATERIALS (IF:4.4[JCR-2023],4.7[5-Year])
EISSN	2079-4991
卷号	12 期号:5
发表状态	已发表
DOI	10.3390/nano12050779
摘要	Nanostructured silver (Ag) and gold (Au) are widely known to be potent biocidal and cytotoxic agents as well as biocompatible nanomaterials. It has been recently reported that combining both metals in a specific chemical composition causes a significant enhancement in their antibacterial activity against antibiotic-resistant bacterial strains, as well as in their anticancer effects, while preserving cytocompatibility properties. In this work, Ag/Au bimetallic nanoparticles over a complete atomic chemical composition range were prepared at 10 at% through a green, highly reproducible, and simple approach using starch as a unique reducing and capping agent. The noble metal nanosystems were thoroughly characterized by different analytical techniques, including UV-visible and FT-IR spectroscopies, XRD, TEM/EDS, XPS and ICP-MS. Moreover, absorption spectra simulations for representative colloidal Ag/Au-NP samples were conducted using FDTD modelling. The antibacterial properties of the bimetallic nanoparticles were determined against multidrug-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus, showing a clear dose-dependent inhibition even at the lowest concentration tested (5 mu g/mL). Cytocompatibility assays showed a medium range of toxicity at low and intermediate concentrations (5 and 10 mu g/mL), while triggering an anticancer behavior, even at the lowest concentration tested, in a process involving reactive oxygen species production per the nanoparticle Au:Ag ratio. In this manner, this study provides promising evidence that the presently fabricated Ag/Au-NPs should be further studied for a wide range of antibacterial and anticancer applications.
关键词	nanomedicine bimetallic nanoparticles antimicrobial resistance anticancer activity green chemistry
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000768268200001
出版者	MDPI
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/165018
专题	物质科学与技术学院_PI研究组_Osamu Terasaki组
通讯作者	Cholula-Diaz, Jorge L.
作者单位	1.Tecnol Monterrey, Sch Sci & Engn, Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico 2.Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA 3.Ctr Invest Mat Avanzados SC CIMAV, Unidad Monterrey, Alianza Norte 202, Apodaca 66628, NL, Mexico 4.CSIC CEI UAM CSIC, IMN, CNM, Isaac Newton 8, Tres Cantos 28760, Spain 5.CSIC, ICMM, Sor Juana Ines de la Cruz 3, Madrid 28049, Spain 6.Univ Zaragoza, CSIC, INMA, Zaragoza 50009, Spain 7.Univ Zaragoza, LMA, Zaragoza 50018, Spain 8.ShanghaiTech Univ, Sch Phys Sci & Technol, Ctr High Resolut Electron Microscopy ChEM, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Nieto-Arguello, Alfonso,Medina-Cruz, David,Perez-Ramirez, Yeremi S.,et al. Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens[J]. NANOMATERIALS,2022,12(5).
APA	Nieto-Arguello, Alfonso.,Medina-Cruz, David.,Perez-Ramirez, Yeremi S..,Perez-Garcia, Sergio A..,Velasco-Soto, Miguel A..,...&Cholula-Diaz, Jorge L..(2022).Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens.NANOMATERIALS,12(5).
MLA	Nieto-Arguello, Alfonso,et al."Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens".NANOMATERIALS 12.5(2022).