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| Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens | |
Nieto-Arguello, Alfonso1; Medina-Cruz, David2; Perez-Ramirez, Yeremi S.1; Perez-Garcia, Sergio A.3; Velasco-Soto, Miguel A.1; Jafari, Zeinab1; De Leon, Israel1; Gonzalez, Maria Ujue4; Huttel, Yves5; Martinez, Lidia5; Mayoral, Alvaro6,7,8  ; Webster, Thomas J.2; Garcia-Martin, Jose M.4; Cholula-Diaz, Jorge L.1
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| 2022-03 | |
| Source Publication | NANOMATERIALS
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| EISSN | 2079-4991 |
| Volume | 12Issue:5 |
| Status | 已发表 |
| DOI | 10.3390/nano12050779 |
| Abstract | Nanostructured silver (Ag) and gold (Au) are widely known to be potent biocidal and cytotoxic agents as well as biocompatible nanomaterials. It has been recently reported that combining both metals in a specific chemical composition causes a significant enhancement in their antibacterial activity against antibiotic-resistant bacterial strains, as well as in their anticancer effects, while preserving cytocompatibility properties. In this work, Ag/Au bimetallic nanoparticles over a complete atomic chemical composition range were prepared at 10 at% through a green, highly reproducible, and simple approach using starch as a unique reducing and capping agent. The noble metal nanosystems were thoroughly characterized by different analytical techniques, including UV-visible and FT-IR spectroscopies, XRD, TEM/EDS, XPS and ICP-MS. Moreover, absorption spectra simulations for representative colloidal Ag/Au-NP samples were conducted using FDTD modelling. The antibacterial properties of the bimetallic nanoparticles were determined against multidrug-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus, showing a clear dose-dependent inhibition even at the lowest concentration tested (5 mu g/mL). Cytocompatibility assays showed a medium range of toxicity at low and intermediate concentrations (5 and 10 mu g/mL), while triggering an anticancer behavior, even at the lowest concentration tested, in a process involving reactive oxygen species production per the nanoparticle Au:Ag ratio. In this manner, this study provides promising evidence that the presently fabricated Ag/Au-NPs should be further studied for a wide range of antibacterial and anticancer applications. |
| Keyword | nanomedicine bimetallic nanoparticles antimicrobial resistance anticancer activity green chemistry |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| WOS ID | WOS:000768268200001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/165018 |
| Collection | 物质科学与技术学院_PI研究组_Osamu Terasaki组 |
| Corresponding Author | Cholula-Diaz, Jorge L. |
| Affiliation | 1.Tecnol Monterrey, Sch Sci & Engn, Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico 2.Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA 3.Ctr Invest Mat Avanzados SC CIMAV, Unidad Monterrey, Alianza Norte 202, Apodaca 66628, NL, Mexico 4.CSIC CEI UAM CSIC, IMN, CNM, Isaac Newton 8, Tres Cantos 28760, Spain 5.CSIC, ICMM, Sor Juana Ines de la Cruz 3, Madrid 28049, Spain 6.Univ Zaragoza, CSIC, INMA, Zaragoza 50009, Spain 7.Univ Zaragoza, LMA, Zaragoza 50018, Spain 8.ShanghaiTech Univ, Sch Phys Sci & Technol, Ctr High Resolut Electron Microscopy ChEM, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China |
| Recommended Citation GB/T 7714 | Nieto-Arguello, Alfonso,Medina-Cruz, David,Perez-Ramirez, Yeremi S.,et al. Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens[J]. NANOMATERIALS,2022,12(5). |
| APA | Nieto-Arguello, Alfonso.,Medina-Cruz, David.,Perez-Ramirez, Yeremi S..,Perez-Garcia, Sergio A..,Velasco-Soto, Miguel A..,...&Cholula-Diaz, Jorge L..(2022).Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens.NANOMATERIALS,12(5). |
| MLA | Nieto-Arguello, Alfonso,et al."Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens".NANOMATERIALS 12.5(2022). |
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