Cell-Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson's Disease

doi:10.3389/fnagi.2022.828457

	Cell-Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson's Disease
	Huang, Maoxin 1,2; Xu, Liang 3; Liu, Jin 1,2; Huang, Pei 1,2; Tan, Yuyan 1,2; Chen, Shengdi1,2,4
	2022-02-25
发表期刊	FRONTIERS IN AGING NEUROSCIENCE (IF:4.1[JCR-2023],4.6[5-Year])
ISSN	1663-4365
卷号	14
发表状态	已发表
DOI	10.3389/fnagi.2022.828457
摘要	Parkinson's disease (PD) is a neurodegenerative movement disorder characterized with dopaminergic neuron (DaN) loss within the substantia nigra (SN). Despite bulk studies focusing on intracellular mechanisms of PD inside DaNs, few studies have explored the pathogeneses outside DaNs, or between DaNs and other cells. Here, we set out to probe the implication of intercellular communication involving DaNs in the pathogeneses of PD at a systemic level with bioinformatics methods. We harvested three online published single-cell/single-nucleus transcriptomic sequencing (sc/snRNA-seq) datasets of human SN (GSE126838, GSE140231, and GSE157783) from the Gene Expression Omnibus (GEO) database, and integrated them with one of the latest integration algorithms called Harmony. We then applied CellChat, the latest cell-cell communication analytic algorithm, to our integrated dataset. We first found that the overall communication quantity was decreased while the overall communication strength was enhanced in PD sample compared with control sample. We then focused on the intercellular communication where DaNs are involved, and found that the communications between DaNs and other cell types via certain signaling pathways were selectively altered in PD, including some growth factors, neurotrophic factors, chemokines, etc. pathways. Our bioinformatics analysis showed that the alteration in intercellular communications involving DaNs might be a previously underestimated aspect of PD pathogeneses with novel translational potential.
关键词	Parkinson's disease sc snRNA-seq CellChat dopaminergic neurons cell-cell communication signaling
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81430022,81771374,81971187,81971183] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; Innovation Program of Shanghai Municipal Education Commission[2017-01-07-00-01-E00046] ; Foundation of Shanghai Municipal Education Commission[2017NKX001]
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000767576200001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/162929
专题	免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Tan, Yuyan; Chen, Shengdi
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Inst Neurol, Shanghai, Peoples R China 3.Tongji Univ, East Hosp, Sch Med, Res Ctr Translat Med, Shanghai, Peoples R China 4.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Lab Translat Res Neurodegenerat Dis, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Huang, Maoxin,Xu, Liang,Liu, Jin,et al. Cell-Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson's Disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14.
APA	Huang, Maoxin,Xu, Liang,Liu, Jin,Huang, Pei,Tan, Yuyan,&Chen, Shengdi.(2022).Cell-Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson's Disease.FRONTIERS IN AGING NEUROSCIENCE,14.
MLA	Huang, Maoxin,et al."Cell-Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson's Disease".FRONTIERS IN AGING NEUROSCIENCE 14(2022).