Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy

doi:10.1016/j.biomaterials.2018.02.018

	Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy
	Wang, Liying1,2,3 ; Huo, Minfeng 1,3; Chen, Yu 1; Shi, Jianlin1
	2018-05
发表期刊	BIOMATERIALS (IF:12.8[JCR-2023],13.1[5-Year])
ISSN	0142-9612
卷号	163 页码:1-13
发表状态	已发表
DOI	10.1016/j.biomaterials.2018.02.018
摘要	Inorganic mesoporous silica-based nanovehicles are highly promising for drug delivery but still suffer from the disadvantages of lacking functionality and poor biodegradability on account of the inert silica framework. Moreover, conventional cancer therapeutics typically employ toxic anticancer drugs or invasive external irradiations, which will inevitably give rise to severe adverse effects and diminished therapeutic outcome. In this work, we report on the iron engineered framework of mesoporous silica nanoparticles (MSNs) to fabricate a nanocatalyst with biodegradable and catalytic framework via a "dissolution-regeneration" strategy (designated as rFeO(x)-HMSN). Based on the abundant overexpressed hydrogen peroxide (H2O2) and mild acidic nature in tumor microenvironment (TME), rFeO(x)-HMSN nanocatalyst could trigger in-situ Fenton-like reactions to produce highly toxic hydroxyl radicals (center dot OH), causing remarkable oxidative damages against tumor cells/xenografts. Additionally, the iron-engineered rFeO(x)-HMSN nanocatalyst could readily collapse via an iron-extraction strategy under protein-rich environment, thereby improving the biodegradability of rFeO(x)-HMSN nanocatalyst. This work paves a promising way to engineer the inert framework of MSN into functional, biodegradable and catalytic nanoplatform, featuring effective tumor-therapeutic outcome and stimuli-responsive biodegradation concurrently. (C) 2018 Elsevier Ltd. All rights reserved.
关键词	Framework engineering Catalytic nanomedicine Fenton-like reaction Tumor microenvironment Coordination degradation
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Youth Innovation Promotion Association, China[2013169]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000428606700001
出版者	ELSEVIER SCI LTD
EI入藏号	20180704802427
EI主题词	Biodegradability ; Biodegradation ; Coordination reactions ; Iron ; Medical nanotechnology ; Mesoporous materials ; Oxidation ; Silica ; Tumors
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Iron:545.1 ; Nanotechnology:761 ; Biochemistry:801.2 ; Chemical Reactions:802.2
WOS关键词	DRUG-DELIVERY SYSTEM ; HYDROGEN-PEROXIDE ; BIOMEDICAL APPLICATIONS ; OXIDE NANOPARTICLES ; FENTON REACTION ; CANCER-THERAPY ; PH ; RELEASE ; AGENTS ; THERANOSTICS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16196
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_施剑林组物质科学与技术学院_博士生
通讯作者	Chen, Yu; Shi, Jianlin
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Wang, Liying,Huo, Minfeng,Chen, Yu,et al. Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy[J]. BIOMATERIALS,2018,163:1-13.
APA	Wang, Liying,Huo, Minfeng,Chen, Yu,&Shi, Jianlin.(2018).Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy.BIOMATERIALS,163,1-13.
MLA	Wang, Liying,et al."Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy".BIOMATERIALS 163(2018):1-13.