Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

doi:10.1136/gutjnl-2015-310514

	Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
	Li, Xiaoguang 1; Yao, Wenbo 1; Yuan, Ya 1; Chen, Peizhan 1; Li, Bin 2; Li, Jingquan 1,3; Chu, Ruiai 1; Song, Haiyun 1,3; Xie, Dong1,3,4 ; Jiang, Xiaoqing 2; Wang, Hui1,3,4
	2017-01
发表期刊	GUT (IF:23.0[JCR-2023],24.5[5-Year])
ISSN	0017-5749
卷号	66 期号:1 页码:157-167
发表状态	已发表
DOI	10.1136/gutjnl-2015-310514
摘要	Objective Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is implicated in various aspects of liver pathology, including HCC. We investigated the feasibility of CCL2/CCR2 as a therapeutic target against HCC.
收录类别	SCI
语种	英语
资助项目	CAS-SIBS Postdoctoral Foundation[2014KIP315]
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
WOS记录号	WOS:000392282900019
出版者	BMJ PUBLISHING GROUP
WOS关键词	MOTIF LIGAND 2 ; INFLAMMATORY MONOCYTES ; CANCER METASTASIS ; LIVER ; CCL2 ; INHIBITION ; EXPRESSION ; RECEPTOR ; CELLS ; RECRUITMENT
原始文献类型	Article
引用统计	被引频次：548[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1591
专题	生命科学与技术学院_特聘教授组_谢东组生命科学与技术学院_特聘教授组_王慧组
通讯作者	Wang, Hui
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China 2.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China 3.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Xiaoguang,Yao, Wenbo,Yuan, Ya,et al. Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma[J]. GUT,2017,66(1):157-167.
APA	Li, Xiaoguang.,Yao, Wenbo.,Yuan, Ya.,Chen, Peizhan.,Li, Bin.,...&Wang, Hui.(2017).Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.GUT,66(1),157-167.
MLA	Li, Xiaoguang,et al."Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma".GUT 66.1(2017):157-167.