TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae
Luo, Junjie1,2,3; Shen, Wei L.3,4; Montell, Craig1,2
2017-01
发表期刊NATURE NEUROSCIENCE
ISSN1097-6256
卷号20期号:1页码:34-41
发表状态已发表
DOI10.1038/nn.4416
摘要Avoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature. These cellular and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature increase. We propose that larvae use low-threshold sensors in the brain to monitor rapid temperature increases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the temperature of the brain rises to dangerous levels.
收录类别SCI
语种英语
资助项目National Nature Science Foundation of China[X-0402-14-002]
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000391085500010
出版者NATURE PUBLISHING GROUP
WOS关键词ION-CHANNEL TRPA1 ; RECEPTOR ; PAIN ; DISCRIMINATION ; CRISPR/CAS9 ; SENSITIVITY ; MECHANISMS ; NOCICEPTOR ; AVOIDANCE ; BEHAVIOR
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1581
专题生命科学与技术学院_PI研究组_沈伟组
通讯作者Montell, Craig
作者单位1.Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
2.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
3.Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
4.ShanghaiTech Univ, Shanghai, Peoples R China
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GB/T 7714
Luo, Junjie,Shen, Wei L.,Montell, Craig. TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae[J]. NATURE NEUROSCIENCE,2017,20(1):34-41.
APA Luo, Junjie,Shen, Wei L.,&Montell, Craig.(2017).TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.NATURE NEUROSCIENCE,20(1),34-41.
MLA Luo, Junjie,et al."TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae".NATURE NEUROSCIENCE 20.1(2017):34-41.
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