TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae
Luo, Junjie1,2,3; Shen, Wei L.3,4; Montell, Craig1,2
2017-01
Source PublicationNATURE NEUROSCIENCE
ISSN1097-6256
Volume20Issue:1Pages:34-41
Status已发表
DOI10.1038/nn.4416
AbstractAvoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature. These cellular and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature increase. We propose that larvae use low-threshold sensors in the brain to monitor rapid temperature increases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the temperature of the brain rises to dangerous levels.
Indexed BySCI
Language英语
Funding ProjectNational Nature Science Foundation of China[X-0402-14-002]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000391085500010
PublisherNATURE PUBLISHING GROUP
WOS KeywordION-CHANNEL TRPA1 ; RECEPTOR ; PAIN ; DISCRIMINATION ; CRISPR/CAS9 ; SENSITIVITY ; MECHANISMS ; NOCICEPTOR ; AVOIDANCE ; BEHAVIOR
Original Document TypeArticle
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1581
Collection生命科学与技术学院_PI研究组_沈伟组
Corresponding AuthorMontell, Craig
Affiliation1.Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA
2.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
3.Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
4.ShanghaiTech Univ, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Luo, Junjie,Shen, Wei L.,Montell, Craig. TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae[J]. NATURE NEUROSCIENCE,2017,20(1):34-41.
APA Luo, Junjie,Shen, Wei L.,&Montell, Craig.(2017).TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.NATURE NEUROSCIENCE,20(1),34-41.
MLA Luo, Junjie,et al."TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae".NATURE NEUROSCIENCE 20.1(2017):34-41.
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