Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis

doi:10.1371/journal.pone.0259570

	Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis
	Hu, Binhong 1,2; Dong, Yuqing 1,3; Zhou, Wenjing 1; Ma, Yichuan 1; Li, Luyao4 ; Fu, Xianhua 1; Zhang, Wenxuan 1; Luo, Yuanyue 1; Pu, Jingyu 1; Deng, Xin 1; Zhang, Rong4 ; Liu, Songqing 1,2
	2021-11-05
发表期刊	PLOS ONE (IF:2.9[JCR-2023],3.3[5-Year])
ISSN	1932-6203
卷号	16 期号:11
发表状态	已发表
DOI	10.1371/journal.pone.0259570
摘要	Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.
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收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000755000800039
出版者	PUBLIC LIBRARY SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/157683
专题	物质科学与技术学院_PI研究组_刘一凡组上海科技大学物质科学与技术学院_硕士生
通讯作者	Zhang, Rong; Liu, Songqing
作者单位	1.Chengdu Normal Univ, Coll Chem & Life Sci, Chengdu, Peoples R China 2.Chengdu Normal Univ, Sichuan Prov Key Lab Dev & Utilizat Characterist, Chengdu, Peoples R China 3.Sichuan Agr Univ, Coll Forestry, Chengdu, Peoples R China 4.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Hu, Binhong,Dong, Yuqing,Zhou, Wenjing,et al. Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis[J]. PLOS ONE,2021,16(11).
APA	Hu, Binhong.,Dong, Yuqing.,Zhou, Wenjing.,Ma, Yichuan.,Li, Luyao.,...&Liu, Songqing.(2021).Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.PLOS ONE,16(11).
MLA	Hu, Binhong,et al."Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis".PLOS ONE 16.11(2021).