High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment

doi:10.1016/j.ymthe.2021.09.015

	High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment
	Ma, Jinhu 1; Zhang, Chunxue 1; Shi, Gang 1; Yue, Dan2 ; Shu, Yongheng 1; Hu, Shichuan 1; Qi, Zhongbing 1; Chen, Yanwei 1; Zhang, Bin 1; Zhang, Yong 1; Huang, Anliang 3; Su, Chao 1; Zhang, Yan 4,5; Deng, Hongxin 1; Cheng, Ping 1
	2022-02-02
发表期刊	MOLECULAR THERAPY (IF:12.1[JCR-2023],11.8[5-Year])
ISSN	1525-0016
EISSN	1525-0024
卷号	30 期号:2
发表状态	已发表
DOI	10.1016/j.ymthe.2021.09.015
摘要	Preclinical and clinical studies have validated the antitumor effects of several oncolytic viruses (OVs). However, the efficacy of OVs is limited when they are administered as monotherapies. Combination therapy is a promising direction for oncolytic virotherapy in the future. A high dose of vitamin C (VitC) exerts anticancer effects by triggering the accretion of substantial amounts of reactive oxygen species (ROS). OVs can induce immunogenic tumor cell death and elicit an antitumor immune response. ROS play an important role in immunogenic cell death (ICD). This study aimed to explore whether highdose VitC in combination with oncolytic adenoviruses (oAds) exhibited a synergistic antitumor effect. High-dose VitC synergized with oAds against tumor by enhancing immunogenic tumor cell death. Combination therapy with high-dose VitC and oAds significantly increased the number of T cells in the tumor microenvironment (TME) and promoted the activation of T cells. Furthermore, the antitumor effect of the combination therapy was CD8+ T cell dependent. In addition, combination therapy with high-dose VitC and oAds reprogramed the immunosuppressive TME. Our study provides a new strategy for combination therapy of OVs.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Science and Technology Major Projects of New Drugs[2018ZX09201018-013] ; National Science and Technology Major Projects for Infectious Diseases Control[2017ZX10203206-004] ; National Natural Science Foundation of China[81101728,82070660] ; Sichuan Regional Innovation Cooperation Project[20QYCX0100] ; Innovation Spark Project of Sichuan University[2018SCUH0084]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS记录号	WOS:000752514200001
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/155855
专题	生命科学与技术学院_PI研究组_许文青组
通讯作者	Cheng, Ping
作者单位	1.Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, 17 Peoples South Rd, Chengdu 610041, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chengdu Fifth Peoples Hosp, Dept Pathol, Chengdu, Peoples R China 4.Sichuan Univ, West China Hosp, Dept Thorac Oncol, Ctr Canc, Chengdu 610041, Peoples R China 5.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Ma, Jinhu,Zhang, Chunxue,Shi, Gang,et al. High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment[J]. MOLECULAR THERAPY,2022,30(2).
APA	Ma, Jinhu.,Zhang, Chunxue.,Shi, Gang.,Yue, Dan.,Shu, Yongheng.,...&Cheng, Ping.(2022).High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment.MOLECULAR THERAPY,30(2).
MLA	Ma, Jinhu,et al."High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment".MOLECULAR THERAPY 30.2(2022).