Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2

doi:10.1016/j.celrep.2022.110319

	Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
	Yan, Rong 1,2; Zhu, Hongyan 1,2; Huang, Piao 1,2; Yang, Min 1,2; Shen, Mengzhen 1,2; Pan, Yuting 1,2; Zhang, Chengqian3 ; Zhou, Xianglian 1,2; Li, Huiliang 4; Ke, Xisong 1,2; Zhang, Weidong 2,4; Hao, Piliang3 ; Qu, Yi 1,2
	2022-02-01
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	38 期号:5
发表状态	已发表
DOI	10.1016/j.celrep.2022.110319
摘要	Wnt/beta-catenin signaling is a well-established driver of colon cancer; however, a targeted therapeutic agent has not reached clinics yet. In the present study, we report that the natural compound liquidambaric acid (LDA) inhibits oncogenic Wnt/beta-catenin signaling in vitro and in vivo through its direct target tumor necrosis factor receptor-associated factor 2 (TRAF2). Mechanistically, TRAF2 positively regulates Wnt signaling by interacting with the N-terminal of beta-catenin via its TRAF-C domain; this interaction is disrupted in presence of LDA. Particularly, a TRAF2/beta-cateniniTCF4/TNIK complex is present in colon cancer cells, where TRAF2 is indispensable for the complex formation, and TRAF2/beta-catenin and beta-catenin/TCF4 interactions are disrupted upon LDA treatment. Our findings not only highlight that TRAF2 is an oncogenic regulator of Wnt/beta-catenin signaling and colon cancer but also provide a lead compound targeting TRAF2 for cancer therapy.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Nat-ural Science Foundation of China[81703757,81874210,81874319,82173845] ; Science and Technology Commission of Shanghai Municipality[18401933500,"21S11900900"] ; Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202004] ; Shanghai Municipal Education Commission["2019-01-07-00-10-E00072","2021-01-07-00-10-E00116"] ; Shanghai Youth Talent Support Program, Shuguang Project[19SG40]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000750963800005
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/154088
专题	生命科学与技术学院_公共科研平台_组学分析平台
通讯作者	Ke, Xisong; Zhang, Weidong; Hao, Piliang; Qu, Yi
作者单位	1.Shanghai Univ Tradit Chinese Med, Ctr Chem Biol, Inst Interdisciplinary Integrat Med Res, 1200 Cailun Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Inst Interdisciplinary Integrat Med Res, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 4.Second Mil Med Univ, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yan, Rong,Zhu, Hongyan,Huang, Piao,et al. Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2[J]. CELL REPORTS,2022,38(5).
APA	Yan, Rong.,Zhu, Hongyan.,Huang, Piao.,Yang, Min.,Shen, Mengzhen.,...&Qu, Yi.(2022).Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2.CELL REPORTS,38(5).
MLA	Yan, Rong,et al."Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2".CELL REPORTS 38.5(2022).