Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds
Liu, Hongyan1; Saxena, Abhishek1; Sidhu, Sachdev S.1,2,3; Wu, Donghui1
2017-01-26
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume8
Status已发表
DOI10.3389/fimmu.2017.00038
AbstractTherapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector cells (T cell, natural killer cell, or macrophage cell) toward target cells have shown great potential to maximize the benefits of antibody therapy. In the past decade, many novel concepts to generate bispecific and multispecific antibodies have evolved successfully into a range of formats from full bispecific immunoglobulin gammas to antibody fragments. Impressively, antibody fragments such as bispecific T-cell engager, bispecific killer cell engager, trispecific killer cell engager, tandem diabody, and dual-affinity-retargeting are showing exciting results in terms of recruiting and activating self-immune effector cells to target and lyse tumor cells. Promisingly, crystallizable fragment (Fc) antigen-binding fragment and monomeric antibody or half antibody may be particularly advantageous to target solid tumors owing to their small size and thus good tissue penetration potential while, on the other hand, keeping Fc-related effector functions such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell-mediated phagocytosis, and extended serum half-life via interaction with neonatal Fc receptor. This review, therefore, focuses on the progress of Fc engineering in generating bispecific molecules and on the use of small antibody fragment as scaffolds for therapeutic development.
KeywordmAbs Fc region FcRn bispecific monovalent heterodimer monomeric Fc Fc antigen-binding
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81572698]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000392744600001
PublisherFRONTIERS MEDIA SA
WOS KeywordNATURAL-KILLER-CELLS ; MONOMERIC IGG1 FC ; SINGLE HUMAN CD4 ; ANTIGEN-BINDING ; IN-VIVO ; HIV-1 INHIBITORS ; FRAGMENT FCAB ; LIGHT-CHAIN ; GAMMA-RI ; ANTI-CD30/CD16A ANTIBODY
Original Document TypeReview
Citation statistics
Cited Times:209[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1529
Collection免疫化学研究所_特聘教授组_抗体工程学实验室
免疫化学研究所_特聘教授组_功能筛选实验室
Corresponding AuthorSidhu, Sachdev S.; Wu, Donghui
Affiliation1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Lab Antibody Engn, Shanghai, Peoples R China
2.Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Banting & Best Dept Med Res, Toronto, ON, Canada
3.Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Dept Mol Genet, Toronto, ON, Canada
First Author AffilicationShanghai Institute for Advanced Immunochemical Studies
Corresponding Author AffilicationShanghai Institute for Advanced Immunochemical Studies
First Signature AffilicationShanghai Institute for Advanced Immunochemical Studies
Recommended Citation
GB/T 7714
Liu, Hongyan,Saxena, Abhishek,Sidhu, Sachdev S.,et al. Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds[J]. FRONTIERS IN IMMUNOLOGY,2017,8.
APA Liu, Hongyan,Saxena, Abhishek,Sidhu, Sachdev S.,&Wu, Donghui.(2017).Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.FRONTIERS IN IMMUNOLOGY,8.
MLA Liu, Hongyan,et al."Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds".FRONTIERS IN IMMUNOLOGY 8(2017).
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