Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium

doi:10.1038/srep43054

	Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium
	Zhou, Ying 1,2; Qiu, Hongxiang 1,3; Xu, Shuhua1,2,4,5
	2017-02-23
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 页码:1-10
发表状态	已发表
DOI	10.1038/srep43054
摘要	Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations.
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program[2016YFC0906403]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000394746800001
出版者	NATURE PUBLISHING GROUP
WOS关键词	POPULATIONS ; ANCESTRY ; DYNAMICS ; DISEASE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1500
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom,Shan, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Univ Hong Kong, Dept Math, Shatin, Hong Kong, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhou, Ying,Qiu, Hongxiang,Xu, Shuhua. Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium[J]. SCIENTIFIC REPORTS,2017,7:1-10.
APA	Zhou, Ying,Qiu, Hongxiang,&Xu, Shuhua.(2017).Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium.SCIENTIFIC REPORTS,7,1-10.
MLA	Zhou, Ying,et al."Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium".SCIENTIFIC REPORTS 7(2017):1-10.