A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis
2017-03-21
发表期刊ONCOTARGET
ISSN1949-2553
卷号8期号:12页码:19684-19698
发表状态已发表
DOI10.18632/oncotarget.14962
摘要The plant homeodomain (PHD) finger-containing proteins have been implicated in many human diseases including cancer. In this study, we found that PHF14, a newly identified PHD finger protein, is highly expressed in lung cancer. The high expression level of PHF14 was associated with adenocarcinoma and poor survival in lung cancer patients. Knocking down PHF14 suppressed cancer cell growth and carcinogenesis, while over-expressing PHF14 promoted cell proliferation. During cell division, PHF14 directly bound to and co-localized with KIF4A (a nuclear motor protein involved in lung carcinogenesis) to form a functional complex. Similarly to the effect of KIF4A depletion, silencing PHF14 in several cell lines caused cell mitotic defects, prolonged M phase, and inhibited cell proliferation. What's more, these two proteins had a synergistic effect on cell proliferation and were significantly co-overexpressed in lung cancer tissues. Our data provide new insights into the biological significance of PHD finger proteins and imply that PHF14 may be a potential biomarker for lung cancer.
关键词PHF14 KIF4A lung carcinogenesis mitosis biomarker
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[31170723] ; National Natural Science Foundation of China[31430055] ; National Natural Science Foundation of China[31190062]
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000396879200084
出版者IMPACT JOURNALS LLC
WOS关键词TUMOR-SUPPRESSOR GENES ; MICROTUBULE DYNAMICS ; EPIGENETIC MARKS ; SPINDLE ; CYTOKINESIS ; PHF14 ; PRC1 ; ORGANIZATION ; PERSPECTIVE ; TARGET
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1462
专题生命科学与技术学院_特聘教授组_季红斌组
生命科学与技术学院_特聘教授组_陈正军组
通讯作者Chen, Zhengjun; Zhang, Zhe
作者单位
1.Chinese Acad Sci, SIBS, SIBCB, Key Lab Syst Biol, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Chest Hosp, Shanghai Lung Tumor Clin Med Ctr, Shanghai, Peoples R China
3.Second Mil Med Univ, Inst Cardiothorac Surg, Changhai Hosp, Shanghai, Peoples R China
4.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China
5.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Shanghai, Peoples R China
6.Chinese Acad Sci, Shanghai Clin Ctr, Shanghai Xu Hui Cent Hosp, Canc Res Ctr, Shanghai, Peoples R China
7.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
8.Chinese Acad Sci, SIBS, SIBCB, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
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GB/T 7714
Zhang, Lin,Huang, Qin,Lou, Jiatao,et al. A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis[J]. ONCOTARGET,2017,8(12):19684-19698.
APA Zhang, Lin.,Huang, Qin.,Lou, Jiatao.,Zou, Liangjian.,Wang, Yiguo.,...&Zhang, Zhe.(2017).A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.ONCOTARGET,8(12),19684-19698.
MLA Zhang, Lin,et al."A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis".ONCOTARGET 8.12(2017):19684-19698.
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