A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis

doi:10.18632/oncotarget.14962

	A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis
	Zhang, Lin 1; Huang, Qin 1; Lou, Jiatao 2; Zou, Liangjian 3; Wang, Yiguo 4; Zhang, Peng 1; Yang, Guang 1; Zhang, Junyi 1; Yu, Lan 1; Yan, Dai 1; Zhang, Chenyi 1; Qiao, Jing 1; Wang, Shuting 1; Wang, Sai 1; Xu, Yongdong 5; Ji, Hongbin1,7,8 ; Chen, Zhengjun1,6,7 ; Zhang, Zhe 1,6
	2017-03-21
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	8 期号:12 页码:19684-19698
发表状态	已发表
DOI	10.18632/oncotarget.14962
摘要	The plant homeodomain (PHD) finger-containing proteins have been implicated in many human diseases including cancer. In this study, we found that PHF14, a newly identified PHD finger protein, is highly expressed in lung cancer. The high expression level of PHF14 was associated with adenocarcinoma and poor survival in lung cancer patients. Knocking down PHF14 suppressed cancer cell growth and carcinogenesis, while over-expressing PHF14 promoted cell proliferation. During cell division, PHF14 directly bound to and co-localized with KIF4A (a nuclear motor protein involved in lung carcinogenesis) to form a functional complex. Similarly to the effect of KIF4A depletion, silencing PHF14 in several cell lines caused cell mitotic defects, prolonged M phase, and inhibited cell proliferation. What's more, these two proteins had a synergistic effect on cell proliferation and were significantly co-overexpressed in lung cancer tissues. Our data provide new insights into the biological significance of PHD finger proteins and imply that PHF14 may be a potential biomarker for lung cancer.
关键词	PHF14 KIF4A lung carcinogenesis mitosis biomarker
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31170723] ; National Natural Science Foundation of China[31430055] ; National Natural Science Foundation of China[31190062]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000396879200084
出版者	IMPACT JOURNALS LLC
WOS关键词	TUMOR-SUPPRESSOR GENES ; MICROTUBULE DYNAMICS ; EPIGENETIC MARKS ; SPINDLE ; CYTOKINESIS ; PHF14 ; PRC1 ; ORGANIZATION ; PERSPECTIVE ; TARGET
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1462
专题	生命科学与技术学院_特聘教授组_季红斌组生命科学与技术学院_特聘教授组_陈正军组
通讯作者	Chen, Zhengjun; Zhang, Zhe
作者单位	1.Chinese Acad Sci, SIBS, SIBCB, Key Lab Syst Biol, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Chest Hosp, Shanghai Lung Tumor Clin Med Ctr, Shanghai, Peoples R China 3.Second Mil Med Univ, Inst Cardiothorac Surg, Changhai Hosp, Shanghai, Peoples R China 4.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China 5.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Shanghai, Peoples R China 6.Chinese Acad Sci, Shanghai Clin Ctr, Shanghai Xu Hui Cent Hosp, Canc Res Ctr, Shanghai, Peoples R China 7.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 8.Chinese Acad Sci, SIBS, SIBCB, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Lin,Huang, Qin,Lou, Jiatao,et al. A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis[J]. ONCOTARGET,2017,8(12):19684-19698.
APA	Zhang, Lin.,Huang, Qin.,Lou, Jiatao.,Zou, Liangjian.,Wang, Yiguo.,...&Zhang, Zhe.(2017).A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis.ONCOTARGET,8(12),19684-19698.
MLA	Zhang, Lin,et al."A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis".ONCOTARGET 8.12(2017):19684-19698.