Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

doi:10.1038/s41556-017-0020-0

	Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells
	Chen, Jun1,2 ; Xu, Na 2; Wang, Chenhui2 ; Huang, Pin 2; Huang, Huanwei 2; Jin, Zhen 2; Yu, Zhongsheng 3; Cai, Tao 2; Jiao, Renjie 3,4; Xi, Rongwen 5,6,7
	2018-02
发表期刊	NATURE CELL BIOLOGY (IF:17.3[JCR-2023],24.2[5-Year])
ISSN	1465-7392
发表状态	已发表
DOI	10.1038/s41556-017-0020-0
摘要	The process through which multiple types of cell-lineage-restricted progenitor cells are specified from multipotent stem cells is unclear. Here we show that, in intestinal stem cell lineages in adult Drosophila, in which the Delta-Notch-signalling-guided progenitor cell differentiation into enterocytes is the default mode, the specification of enteroendocrine cells (EEs) is initiated by transient Scute activation in a process driven by transcriptional self-stimulation combined with a negative feedback regulation between Scute and Notch targets. Scute activation induces asymmetric intestinal stem cell divisions that generate EE progenitor cells. The mitosis-inducing and fate-inducing activities of Scute guide each EE progenitor cell to divide exactly once prior to its terminal differentiation, yielding a pair of EEs. The transient expression of a fate inducer therefore specifies both type and numbers of committed progenitor cells originating from stem cells, which could represent a general mechanism used for diversifying committed progenitor cells from multipotent stem cells.
收录类别	SCI
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/144318
专题	个人在本单位外知识产出
通讯作者	Xi, Rongwen
作者单位	1.Graduate School of Peking Union Medical College, Beijing, China 2.National Institute of Biological Sciences, Beijing, China. 3.Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 4.Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China 5.Graduate School of Peking Union Medical College, Beijing, China. xirongwen@nibs.ac.cn 6.National Institute of Biological Sciences, Beijing, China. xirongwen@nibs.ac.cn 7.Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. xirongwen@nibs.ac.cn
推荐引用方式 GB/T 7714	Chen, Jun,Xu, Na,Wang, Chenhui,et al. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells[J]. NATURE CELL BIOLOGY,2018.
APA	Chen, Jun.,Xu, Na.,Wang, Chenhui.,Huang, Pin.,Huang, Huanwei.,...&Xi, Rongwen.(2018).Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.NATURE CELL BIOLOGY.
MLA	Chen, Jun,et al."Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells".NATURE CELL BIOLOGY (2018).