NLRs guard metabolism to coordinate pattern- and effector-triggered immunity

doi:10.1038/s41586-021-04219-2

	NLRs guard metabolism to coordinate pattern- and effector-triggered immunity
	Zhai, Keran 1; Liang, Di 1,2; Li, Helin 1,3; Jiao, Fangyuan1,4 ; Yan, Bingxiao 1,2; Liu, Jing 1,2; Lei, Ziyao 1,2; Huang, Li 1,2; Gong, Xiangyu 1,2; Wang, Xin 1; Miao, Jiashun 1; Wang, Yichuan 5; Liu, Ji-Yun 1; Zhang, Lin 6; Wang, Ertao 1; Deng, Yiwen 1; Wen, Chi-Kuang 1; Guo, Hongwei 5; Han, Bin 1; He, Zuhua1,4
	2022-01-13
发表期刊	NATURE (IF:50.5[JCR-2023],54.4[5-Year])
ISSN	0028-0836
EISSN	1476-4687
发表状态	已发表
DOI	10.1038/s41586-021-04219-2
摘要	Pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in plants enable them to respond to pathogens by activating the production of defence metabolites that orchestrate immune responses(1-4). How the production of defence metabolites is promoted by immune receptors and coordinated with broad-spectrum resistance remains elusive. Here we identify the deubiquitinase PICI1 as an immunity hub for PTI and ETI in rice (Oryza sativa). PICI1 deubiquitinates and stabilizes methionine synthetasesto activate methionine-mediated immunity principally through biosynthesis ofthe phytohormone ethylene. PICI1 istargeted for degradation by blast fungal effectors, including AvrPi9, to dampen PTI. Nucleotide-binding domain, leucine-rich-repeat-containing receptors (NLRB) in the plant immune system, such as PigmR, protect PICI1 from effector-mediated degradation to reboot the methionine-ethylene cascade. Natural variation in the PICI1 gene contributes to divergence in basal blast resistance between the rice subspecies indica andjaponica. Thus, NLRs govern an arms race with effectors, using a competitive mode that hinges on a critical defence metabolic pathway to synchronize PTI with ETI and ensure broad-spectrum resistance.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[32088102,31720103913,"U20A2021"] ; Chinese Academy of Sciences["XDB27040201","XDA24010304"] ; National Key Research and Development Program of China[2016YFD0100600] ; Science and Technology Commission of Shanghai Municipality[19391900300] ; Project of Special Funding for Crop Science Discipline Development of Yangzhou University[yzuxk202006] ; National Postdoctoral Program for Innovative Talents[BX20190346]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000730550300007
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/138708
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_何祖华组
通讯作者	He, Zuhua
作者单位	1.Chinese Acad Sci, Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Henan Univ, Sch Life Sci, Kaifeng, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 5.Southern Univ Sci & Technol, Inst Plant & Food Sci, Dept Biol, Shenzhen, Peoples R China 6.Yangzhou Univ, Jiangsu Key Lab Crop Genom & Mol Breeding, Yangzhou, Jiangsu, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhai, Keran,Liang, Di,Li, Helin,et al. NLRs guard metabolism to coordinate pattern- and effector-triggered immunity[J]. NATURE,2022.
APA	Zhai, Keran.,Liang, Di.,Li, Helin.,Jiao, Fangyuan.,Yan, Bingxiao.,...&He, Zuhua.(2022).NLRs guard metabolism to coordinate pattern- and effector-triggered immunity.NATURE.
MLA	Zhai, Keran,et al."NLRs guard metabolism to coordinate pattern- and effector-triggered immunity".NATURE (2022).