Immunochemical engineering of cell surfaces to generate virus resistance

doi:10.1073/pnas.1702764114

KMS > 免疫化学研究所 > 特聘教授组 > Richard A. Lerner组

	Immunochemical engineering of cell surfaces to generate virus resistance
	Xie, Jia 1; Sok, Devin 2; Wu, Nicholas C.3; Zheng, Tianqing 1; Zhang, Wei4 ; Burton, Dennis R.2; Lerner, Richard A.1
	2017-05-02
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	114 期号:18 页码:4655-4660
发表状态	已发表
DOI	10.1073/pnas.1702764114
摘要	Modern immunochemical engineering allows the creation of cells that either secrete antibodies or incorporate them into various cellular compartments, including the plasma membrane. Because the receptors for most viruses are known, if one can achieve the proper stoichiometry and geometry, plasma membrane-associated antibodies to these receptors should block viral infection. In this report, we test this concept for two different viruses, human rhinovirus and HIV. Plasma membrane-tethered antibodies efficiently rendered cells permanently nonpermissive for infection by both these viruses. Membrane-bound antibodies were much more efficient than free antibody in preventing infection, likely because of the effective molarity of membrane bound antibodies. Such resistant cells may restore immune-competence to otherwise compromised HIV patients.
关键词	HIV cell surfaces prevention
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000400358000040
出版者	NATL ACAD SCIENCES
WOS关键词	COMBINATORIAL ANTIBODY LIBRARIES ; NEUTRALIZING ANTIBODIES ; CCR5 ; HIV ; TYPE-1
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1379
专题	免疫化学研究所_特聘教授组_抗体设计学实验室
通讯作者	Lerner, Richard A.
作者单位	1.Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA 2.Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA 3.Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA 4.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Xie, Jia,Sok, Devin,Wu, Nicholas C.,et al. Immunochemical engineering of cell surfaces to generate virus resistance[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017,114(18):4655-4660.
APA	Xie, Jia.,Sok, Devin.,Wu, Nicholas C..,Zheng, Tianqing.,Zhang, Wei.,...&Lerner, Richard A..(2017).Immunochemical engineering of cell surfaces to generate virus resistance.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,114(18),4655-4660.
MLA	Xie, Jia,et al."Immunochemical engineering of cell surfaces to generate virus resistance".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114.18(2017):4655-4660.