Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems

doi:10.1021/acsami.7b05383

	Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems
	Wang, Ting 1; Wang, Lu 2,3; Li, Xiaoming4 ; Hu, Xingjie 2,3; Han, Yuping 1; Luo, Yao 1; Wan, Zejun 2,3; Li, Qian 2,3; Aldalbahi, Ali 5; Wang, Lihua 2,3; Song, Shiping 2,3; Fang, Chunhai 2,3; Zhao, Yun 1; Wang, Maolin 1; Chen, Nan 2,3
	2017-06-07
发表期刊	ACS APPLIED MATERIALS & INTERFACES (IF:8.3[JCR-2023],8.7[5-Year])
ISSN	1944-8244
卷号	9 期号:22 页码:18619-18625
发表状态	已发表
DOI	10.1021/acsami.7b05383
摘要	Nanopartides (NPs) have ahowia great promise as intracellular imaging probes or nanocarriers and are increasingly being used in biomedical applications. A detailed understanding of how NPs get "in and our of cells is important for developing new nanomkterials with improved selectivity and less cytotoxicify. Both cellular and chemical characteristics have been proven to regulate the cellular uptake of NPs. However, the exocytosis Ness and its regulation are less explored. Herein, we investigated the size-regulated endocytosis and exocytosis of carboxylated polystyrene (PS). NPs, PS NPs with a smaller site were endocytosed mainly through the clathrin-dependent pathlway, whereas PS NPs with a larger size preferred caveolae-mediated endocytosis, Furthermore, our results revealed exocytosis of larger PS NPs and tracked the dynamic process at the single-particle level. These results a indicate that particle size is a key factor for the regulation intracellular trafficking of NPs and provide new insight into the :development of more effective cellular nanocarriers.
关键词	nanopartides imaging exocytosis endocytosis intracellular trafficking
收录类别	SCI ; EI
语种	英语
资助项目	Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH019]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000403136400026
出版者	AMER CHEMICAL SOC
EI入藏号	20172403753355
EI主题词	Imaging techniques ; Medical applications ; Molecular biology ; Particle size ; Polystyrenes
EI分类号	Biology:461.9 ; Imaging Techniques:746 ; Nanotechnology:761 ; Organic Polymers:815.1.1 ; Solid State Physics:933
WOS关键词	GRAPHENE OXIDE NANOSHEETS ; ENGINEERED NANOPARTICLES ; CELLULAR UPTAKE ; CONJUGATED POLYMER ; ENDOTHELIAL-CELLS ; ENDOCYTOSIS ; MECHANISMS ; ENTRY ; CYTOTOXICITY ; EXOCYTOSIS
原始文献类型	Article
通讯作者	Wang, Maolin ; Chen, Nan
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1338
专题	生命科学与技术学院_公共科研平台_分子影像平台
通讯作者	Wang, Maolin; Chen, Nan
作者单位	1.Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.King Saud Univ, Chem Dept, Riyadh 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Wang, Ting,Wang, Lu,Li, Xiaoming,et al. Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18619-18625.
APA	Wang, Ting.,Wang, Lu.,Li, Xiaoming.,Hu, Xingjie.,Han, Yuping.,...&Chen, Nan.(2017).Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems.ACS APPLIED MATERIALS & INTERFACES,9(22),18619-18625.
MLA	Wang, Ting,et al."Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18619-18625.