Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition-enantioselective protonation enabled by cooperative catalysis

doi:10.1039/d1qo00970b

	Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition-enantioselective protonation enabled by cooperative catalysis
	Chen, Yunrong; Ye, Xueqian; He, Faqian; Yang, Xiaoyu
	2021-10-12
发表期刊	ORGANIC CHEMISTRY FRONTIERS (IF:4.6[JCR-2023],4.3[5-Year])
ISSN	2052-4110
EISSN	2052-4129
卷号	8 期号:20 页码:5804-5809
发表状态	已发表
DOI	10.1039/d1qo00970b
摘要	An efficient radical conjugate addition/enantioselective protonation process was developed for N-aryl glycines and alkenyl oxazolines enabled by the cooperative photoredox catalysis and chiral phosphoric acid catalysis, which generated a series of chiral oxazolines bearing an α-stereocenter with high enantioselectivities. The facile transformations of the chiral oxazoline products into enantioenriched lactams and γ-amino esters bearing α-stereocenters demonstrate the value of this method. This journal is © the Partner Organisations.
关键词	Amides Amino acids Catalysis Protonation Alkenyl Asymmetric synthesis Chiral oxazolines Cooperative catalysis Enantioselective Oxazolines Protonations Radical addition Radical conjugate additions Stereocenters
收录类别	SCI ; SCIE ; EI ; CCR ; IC
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000688132500001
出版者	Royal Society of Chemistry
EI入藏号	20214311050914
EI主题词	Enantioselectivity
EI分类号	801.4 Physical Chemistry ; 802.2 Chemical Reactions ; 804.1 Organic Compounds
原始文献类型	Journal article (JA)
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/133433
专题	物质科学与技术学院_博士生物质科学与技术学院_PI研究组_杨晓瑜组物质科学与技术学院_硕士生
通讯作者	Chen, Yunrong; Yang, Xiaoyu
作者单位	School of Physical Science and Technology, ShanghaiTech University, Shanghai; 201210, China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Chen, Yunrong,Ye, Xueqian,He, Faqian,et al. Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition-enantioselective protonation enabled by cooperative catalysis[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(20):5804-5809.
APA	Chen, Yunrong,Ye, Xueqian,He, Faqian,&Yang, Xiaoyu.(2021).Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition-enantioselective protonation enabled by cooperative catalysis.ORGANIC CHEMISTRY FRONTIERS,8(20),5804-5809.
MLA	Chen, Yunrong,et al."Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition-enantioselective protonation enabled by cooperative catalysis".ORGANIC CHEMISTRY FRONTIERS 8.20(2021):5804-5809.